Villarreal H, Arcila H, Ramírez M A, Sierra P
Mayo Clin Proc. 1977 Jun;52(6):383-6.
The effect of guancydine (1-cyano-3-tert-amylguanidine) on systemic and renal hemodynamics was studied in nine patients with arterial hypertension. Antihypertensive drugs were withheld for 15 days before beginning the investigation. Average sodium intake was 105 meq/24 hours in some patients and 25 meq/24 hours in others. Patients received placebo during a control period that averaged 14 days. Guancydine was given for 7 to 18 days at an average dose of 21 mg/kg of body weight. Although mean arterial blood pressure decreased significantly in all patients, it reached normal levels in only two. There was no change in cardiac output. Glomerular filtration rate and renal plasma flow remained unchanged, whereas urinary sodium excretion diminished, suggesting an activation of the renin-angiotensin-aldosterone system. A substantial gain in body weight was noted. Nausea, vomiting, constipation, somnolence, restlessness, mental confusion, asthenia, and urine retention were observed. The anti-angiotensin effect of guancydine that has been described in animals was not observed.
研究了胍乙啶（1-氰基-3-叔戊基胍）对9例高血压患者全身和肾脏血流动力学的影响。在开始研究前，停用抗高血压药物15天。部分患者平均钠摄入量为105毫当量/24小时，其他患者为25毫当量/24小时。在平均为期14天的对照期内，患者接受安慰剂治疗。胍乙啶给药7至18天，平均剂量为21毫克/千克体重。虽然所有患者的平均动脉血压均显著下降，但仅2例降至正常水平。心输出量无变化。肾小球滤过率和肾血浆流量保持不变，而尿钠排泄减少，提示肾素-血管紧张素-醛固酮系统激活。体重显著增加。观察到恶心、呕吐、便秘、嗜睡、烦躁、精神错乱、乏力和尿潴留。未观察到动物实验中所描述的胍乙啶的抗血管紧张素作用。
