Hărăgus S T, Uza G, Duncea C
Cor Vasa. 1977;19(3):214-9.
Guancydine (1-cyano-3-tert-amylguanidine) lowered within normal limits the tensional values in an interval of four hours after its administration in eight out of nine hypertensive patients under experiment. The hypotensive effect of a single oral dose of 500-750 mg persists for about 6-7 hours after its administration. Guancydine does not impair the vasopressor response to angiotensin II but reduces the action of this peptide on the excretion of water, Na, K and Ca through urine. The hypotensive effect of Guancydine is associated with a decrease of platelet adhesiveness and an activation of fibrinolysis. In view of this fact, Guancydine might play a role in the prophylaxis of complications of arterial hypertension - atherosclerosis and trombosis. The increase of venous blood oxygenation after Guancydine could be attributed to the opening of arterio-venous shunts or to the reduction of tissular extraction of oxygen. Guancydine does not seem to be toxic. It produced, in some patients, slight headache and orthostatic hypotension, especially during the first hours after administration.
胍环定（1-氰基-3-叔戊基胍）使9名接受实验的高血压患者中的8名在给药后4小时内血压值降至正常范围。单次口服500 - 750毫克的降压作用在给药后持续约6 - 7小时。胍环定不损害对血管紧张素II的升压反应，但可降低该肽对水、钠、钾和钙经尿液排泄的作用。胍环定的降压作用与血小板黏附性降低和纤维蛋白溶解激活有关。鉴于这一事实，胍环定可能在预防动脉高血压并发症——动脉粥样硬化和血栓形成中发挥作用。胍环定给药后静脉血氧合增加可能归因于动静脉分流的开放或组织对氧摄取的减少。胍环定似乎无毒。在一些患者中，它会引起轻微头痛和体位性低血压，尤其是在给药后的最初几个小时。
