Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, China.
Department of Psychiatry, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, China.
Int J Neurosci. 2021 Dec;131(12):1173-1180. doi: 10.1080/00207454.2020.1782905. Epub 2020 Jun 26.
Mild cognitive impairment (MCI) is an intermediate state between normal aging and dementia and is characterized by pathological cognitive decline. The study aimed at revealing the risk of MCI progressing to dementia through a follow-up investigation.
In 2011, 441 MCI subjects were recruited, and the disease status was tracked by the follow-up survey in 2017. Subjects with MCI stable (MCIs; = 356) and MCI progressed into dementia (MCIp; = 77) were analysed in our study. Community-dwelling old people of age ≥ 55 were recruited from 30 streets and 24 committees (or communities) of the Pudong New District (Shanghai, China). Neuropsychological tests of MMSE, MoCA, 17-item HAMD-17, ADL and HIS were performed. Additionally, the correlations of neuropsychological items and MCIp were explored by univariate and multivariate regression analyses.
MCIp patients had the lower MMSE and MoCA total scores, whereas the ADL, and HIS total score in MCIp group were higher than in MCIs group. The univariate analysis revealed age, attention (MoCA), visuospatial/executive, number of births, marital status and attention and calculation were significant predictors of MCI progression. In multivariate analysis, age was an independent risk factor of MCI aggravating, while attention (MoCA) was independent protective factor for MCI progression.
Age and worsening attention but not depression in MCI patients were independently associated with the progression of dementia in a 6-year follow-up period.
轻度认知障碍（MCI）是正常衰老和痴呆之间的中间状态，其特征是病理性认知下降。本研究旨在通过随访调查揭示 MCI 进展为痴呆的风险。
2011 年，招募了 441 名 MCI 受试者，并在 2017 年通过随访调查跟踪疾病状况。我们的研究分析了 MCI 稳定（MCIs；=356）和 MCI 进展为痴呆（MCIp；=77）的受试者。从中国上海浦东新区的 30 个街道和 24 个委员会（或社区）招募年龄≥55 岁的社区居住老年人。进行 MMSE、MoCA、17 项汉密尔顿抑郁量表（HAMD-17）、ADL 和 HIS 等神经心理学测试。此外，通过单变量和多变量回归分析探讨了神经心理学项目与 MCIp 的相关性。
MCIp 患者的 MMSE 和 MoCA 总分较低，而 MCIp 组的 ADL 和 HIS 总分较高。单变量分析显示，年龄、注意力（MoCA）、视空间/执行、生育次数、婚姻状况和注意力与计算是 MCI 进展的显著预测因素。在多变量分析中，年龄是 MCI 加重的独立危险因素，而注意力（MoCA）是 MCI 进展的独立保护因素。
在 6 年的随访期间，年龄和 MCI 患者注意力（MoCA）的恶化而不是抑郁与痴呆的进展独立相关。
