Chang Eric, Fu Cong, Coon Steven L, Alon Shahar, Bozinoski Marjan, Breymaier Matthew, Bustos Diego M, Clokie Samuel J, Gothilf Yoav, Esnault Caroline, Michael Iuvone P, Mason Christopher E, Ochocinska Margaret J, Tovin Adi, Wang Charles, Xu Pinxian, Zhu Jinhang, Dale Ryan, Klein David C
Bioinformatics and Scientific Programming Core, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
Section on Neuroendocrinology, Program in Developmental Endocrinology and Genetics, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
J Pineal Res. 2020 Oct;69(3):e12673. doi: 10.1111/jpi.12673. Epub 2020 Jul 8.
The website and database https://snengs.nichd.nih.gov provides RNA sequencing data from multi-species analysis of the pineal glands from zebrafish (Danio rerio), chicken (White Leghorn), rat (Rattus novegicus), mouse (Mus musculus), rhesus macaque (Macaca mulatta), and human (Homo sapiens); in most cases, retinal data are also included along with results of the analysis of a mixture of RNA from tissues. Studies cover day and night conditions; in addition, a time series over multiple hours, a developmental time series and pharmacological experiments on rats are included. The data have been uniformly re-processed using the latest methods and assemblies to allow for comparisons between experiments and to reduce processing differences. The website presents search functionality, graphical representations, Excel tables, and track hubs of all data for detailed visualization in the UCSC Genome Browser. As more data are collected from investigators and improved genomes become available in the future, the website will be updated. This database is in the public domain and elements can be reproduced by citing the URL and this report. This effort makes the results of 21st century transcriptome profiling widely available in a user-friendly format that is expected to broadly influence pineal research.
网站和数据库https://snengs.nichd.nih.gov提供了来自斑马鱼（Danio rerio）、鸡（白来航鸡）、大鼠（Rattus novegicus）、小鼠（Mus musculus）、恒河猴（Macaca mulatta）和人类（Homo sapiens）松果体多物种分析的RNA测序数据；在大多数情况下，视网膜数据以及组织RNA混合物的分析结果也包含在内。研究涵盖白天和夜晚条件；此外，还包括大鼠数小时的时间序列、发育时间序列和药理学实验。这些数据已使用最新方法和组件进行统一重新处理，以便进行实验间比较并减少处理差异。该网站提供搜索功能、图形表示、Excel表格以及所有数据的轨道中心，以便在UCSC基因组浏览器中进行详细可视化。随着未来从研究人员那里收集到更多数据以及更完善的基因组可用，该网站将进行更新。此数据库属于公共领域，其内容可通过引用URL和本报告进行复制。这项工作使21世纪转录组分析的结果以用户友好的格式广泛可用，预计将对松果体研究产生广泛影响。
