Department of Medicine, North Shore Medical Center, 81 Highland Ave., Salem, MA, 01970, USA.
Department of Medicine, Tufts University School of Medicine, Boston, MA, USA.
Dig Dis Sci. 2021 May;66(5):1461-1476. doi: 10.1007/s10620-020-06402-3. Epub 2020 Jun 13.
BACKGROUND/AIM: The prevalence, characteristics, burden and trends of primary biliary cholangitis (PBC) hospitalizations in the USA remain unclear.
We identified primary PBC hospitalizations from the National Inpatient Sample (NIS) 2007 through 2014 using ICD-9-CM codes. We calculated the rates and trends of hospitalization for PBC per 100,000 US population among each gender (males and females) and racial categories (Whites, Blacks, Hispanics and other racial minorities), and measured the predictors of hospitalization, and of mortality, charges and length of stay (LOS) among PBC hospitalizations.
There were 8460 (weighted: 41,191) PBC hospitalizations between 2007 and 2014. The mean national PBC hospitalization rate was 2.2 cases per 100,000 population (2.2/100,000), increasing from 1.7/100,000 (2007) to 2.5/100,000 (2014). From 2007 to 2014, the in-hospital mortality and LOS were unchanged while the charges increased from $65,993 to $73,093 ($225 million to $447 million overall expenses). Compared to Whites, the PBC hospitalization rate was 12% higher among Hispanics (RR: 1.12 [1.09-1.16]), 53% lower in Blacks (RR: 0.47 [0.45-0.49]) and 5% lower among other racial minorities (0.95 [0.91-0.99]). The rate was higher among females (RR:4.02 [3.93-4.12]) compared to males. On multivariate analysis, Blacks and other racial minorities, respectively, had higher odds of mortality (AOR: 1.47 [1.03-2.10] and 1.33 [0.96-1.84]), while other racial minorities had longer LOS (7.0 vs. 5.6 days) and higher hospital charges ($48,984 vs. $41,495) when compared to Whites.
The hospitalization rate and burden of PBC in the USA have increased disproportionately among females and Hispanics with higher mortality in Blacks.
背景/目的：美国原发性胆汁性胆管炎（PBC）住院的患病率、特征、负担和趋势尚不清楚。
我们使用 ICD-9-CM 代码从 2007 年至 2014 年的国家住院患者样本（NIS）中确定了原发性 PBC 住院患者。我们计算了每 10 万美国人口中男性和女性以及白种人、黑种人、西班牙裔和其他少数种族群体中 PBC 住院率和趋势，并衡量了 PBC 住院的住院、死亡率、费用和住院时间（LOS）的预测因素。
2007 年至 2014 年间共有 8460 例（加权：41191 例）PBC 住院患者。全国 PBC 住院率平均为每 10 万人 2.2 例（2.2/10 万），从 2007 年的 1.7/10 万增加到 2014 年的 2.5/10 万。2007 年至 2014 年，住院死亡率和 LOS 保持不变，而费用从 65993 美元增加到 73093 美元（总费用从 2.25 亿美元增加到 4.47 亿美元）。与白人相比，西班牙裔的 PBC 住院率高 12%（RR：1.12[1.09-1.16]），黑人低 53%（RR：0.47[0.45-0.49]），其他少数族裔低 5%（0.95[0.91-0.99]）。女性（RR：4.02[3.93-4.12]）的比率高于男性。多变量分析显示，黑人（AOR：1.47[1.03-2.10]）和其他少数族裔（AOR：1.33[0.96-1.84]）的死亡率更高，而其他少数族裔的 LOS（7.0 天对 5.6 天）和住院费用（48984 美元对 41495 美元）更高。
美国 PBC 的住院率和负担不成比例地增加了，女性和西班牙裔的发病率较高，黑人的死亡率较高。
