Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, Maharashtra, India.
Chem Commun (Camb). 2020 Aug 7;56(61):8569-8590. doi: 10.1039/d0cc02659j. Epub 2020 Jun 15.
Catalytic processes in protecting-group-free syntheses of natural products are fast emerging towards achieving the goal of efficiency and economy in total synthesis. Present day sustainable development in synthesis of natural products does not permit the luxury of using stoichiometric reagents and protecting groups. Catalysis and step-economy can contribute significantly toward economy and efficiency of synthesis. This feature article details the ingenious efforts by many researchers in the last couple of years toward concise total syntheses, based on catalytic steps and protecting-group-free-strategies. These would again serve as guidelines in future development of reagents and catalysts aimed at achieving higher efficiency and chemoselectivity to the point that catalysis and protecting-group-free synthesis will be an accepted common practice.
在天然产物的无保护基合成中，催化过程正在迅速发展，以实现全合成的高效和经济目标。当今天然产物合成的可持续发展不允许使用化学计量试剂和保护基团的奢侈。催化和步骤经济性可以为合成的经济性和效率做出重大贡献。本文详细介绍了过去几年许多研究人员在基于催化步骤和无保护基策略的简洁全合成方面所做的巧妙努力。这些又将作为未来旨在提高效率和化学选择性的试剂和催化剂开发的指导原则，以至于催化和无保护基合成将成为一种被普遍接受的常见做法。
