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Intravenous Injection of Muse Cells as a Potential Therapeutic Approach for Epidermolysis Bullosa.

作者信息

Fujita Yasuyuki, Komatsu Miho, Lee San Eun, Kushida Yoshihiro, Nakayama-Nishimura Chihiro, Matsumura Wakana, Takashima Shota, Shinkuma Satoru, Nomura Toshifumi, Masutomi Naoya, Kawamura Makoto, Dezawa Mari, Shimizu Hiroshi

机构信息

Department of Dermatology, Graduate School of Medicine and Faculty of Medicine, Hokkaido University, Sapporo, Japan; Department of Dermatology, Sapporo City General Hospital, Sapporo, Japan.

Department of Dermatology, Graduate School of Medicine and Faculty of Medicine, Hokkaido University, Sapporo, Japan.

出版信息

J Invest Dermatol. 2021 Jan;141(1):198-202.e6. doi: 10.1016/j.jid.2020.05.092. Epub 2020 Jun 12.

DOI:10.1016/j.jid.2020.05.092
PMID:32540249
Abstract
摘要

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1
Intravenous Injection of Muse Cells as a Potential Therapeutic Approach for Epidermolysis Bullosa.静脉注射缪斯细胞作为大疱性表皮松解症的一种潜在治疗方法。
J Invest Dermatol. 2021 Jan;141(1):198-202.e6. doi: 10.1016/j.jid.2020.05.092. Epub 2020 Jun 12.
2
[Phenytoin therapy in recessive dystrophic epidermolyses (epidermolysis bullosa dystrophica type Hallopeau-Siemens and epidermolysis bullosa dystrophica inversa)].[苯妥英钠治疗隐性营养不良性大疱性表皮松解症（Hallopeau-Siemens型营养不良性大疱性表皮松解症和反向性营养不良性大疱性表皮松解症）]
Z Hautkr. 1983 Apr 15;58(8):555-74.
3
Epidermolysis bullosa pruriginosa showing good response to low-dose thalidomide - a report of two cases.痒疹性表皮松解症对小剂量反应良好-两例报告。
Dermatol Ther. 2014 Jan-Feb;27(1):60-3. doi: 10.1111/dth.12047. Epub 2013 Apr 2.
4
[Epidermolysis bullosa atrophicans gravis. Report of a therapeutic trial with dapsone].[重症萎缩性大疱性表皮松解症。氨苯砜治疗试验报告]
Monatsschr Kinderheilkd. 1988 Mar;136(3):140-2.
5
Acquired epidermolysis bullosa treated with a gold compound.用金化合物治疗获得性大疱性表皮松解症。
Acta Derm Venereol. 1979;59(4):378-9.
6
Epidermolysis bullosa progressiva: a therapeutic suggestion.进行性大疱性表皮松解症：一种治疗建议。
J Am Acad Dermatol. 1988 Jan;18(1 Pt 1):141-3. doi: 10.1016/s0190-9622(88)80050-1.
7
Self-initiated use of topical cannabidiol oil for epidermolysis bullosa.表皮松解性大疱病患者自行使用局部大麻二酚油剂的情况。
Pediatr Dermatol. 2018 Jul;35(4):e224-e227. doi: 10.1111/pde.13545. Epub 2018 May 22.
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Understanding the Potential Promise and Pitfalls of Intravenous Gentamicin as a Therapy for Epidermolysis Bullosa.了解静脉注射庆大霉素作为大疱性表皮松解症治疗方法的潜在前景与风险。
JAMA Dermatol. 2022 Apr 1;158(4):356-358. doi: 10.1001/jamadermatol.2021.5630.
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[The effect of collagenase inhibition on bullous eruption and healing process in epidermolysis bullosa].[胶原酶抑制对大疱性表皮松解症中大疱性皮疹及愈合过程的影响]
Hautarzt. 1979 Feb;30(2):89-91.
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[Transurethral alprostadil administration with MUSE ("Medicated Urethral System for Erection"). Current overview and personal experiences].[使用MUSE（“用于勃起的药物尿道系统”）经尿道给予前列地尔。当前综述及个人经验]
Urologe A. 1998 Jul;37(4):410-6. doi: 10.1007/s001200050199.

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Comparison of MSCs and Muse cells: the possible use for healthspan optimization.间充质干细胞与多能分化应激耐受细胞的比较：对健康寿命优化的潜在应用
Biogerontology. 2025 Jul 2;26(4):139. doi: 10.1007/s10522-025-10275-2.
2
Nose-to-brain delivery of human muse cells enhances structural and functional recovery in the murine ischemic stroke model.人多能分化应激耐受细胞经鼻至脑递送可增强小鼠缺血性中风模型的结构和功能恢复。
Sci Rep. 2025 May 9;15(1):16243. doi: 10.1038/s41598-025-96451-3.
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Sphingosine-1-Phosphate Receptor 2 Agonist Mobilises Endogenous Muse Cells to Repair Damaged Myocardial Tissue in Male Rabbits.
1-磷酸鞘氨醇受体2激动剂动员内源性多能分化应激耐受细胞修复雄性兔受损心肌组织
J Cell Mol Med. 2025 Apr;29(8):e70447. doi: 10.1111/jcmm.70447.
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Macrophage- and pluripotent-like reparative Muse cells are unique endogenous stem cells distinct from other somatic stem cells.巨噬细胞样和多能样修复性缪斯细胞是不同于其他体细胞干细胞的独特内源性干细胞。
Front Bioeng Biotechnol. 2025 Mar 27;13:1553382. doi: 10.3389/fbioe.2025.1553382. eCollection 2025.
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Structural reconstruction of mouse acute aortic dissection by intravenously administered human Muse cells without immunosuppression.静脉注射人多能分化应激耐受细胞对小鼠急性主动脉夹层进行结构重建，无需免疫抑制。
Commun Med (Lond). 2024 Sep 9;4(1):174. doi: 10.1038/s43856-024-00597-6.
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Treatment of Epidermolysis Bullosa and Future Directions: A Review.大疱性表皮松解症的治疗及未来方向：综述
Dermatol Ther (Heidelb). 2024 Aug;14(8):2059-2075. doi: 10.1007/s13555-024-01227-8. Epub 2024 Aug 2.
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Multilineage-differentiating stress-enduring cells: a powerful tool for tissue damage repair.多谱系分化应激耐受细胞：组织损伤修复的有力工具。
Front Cell Dev Biol. 2024 May 30;12:1380785. doi: 10.3389/fcell.2024.1380785. eCollection 2024.
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Exploring SSEA3 as an emerging biomarker for assessing the regenerative potential of dental pulp-derived stem cells.探索阶段特异性胚胎抗原3（SSEA3）作为评估牙髓来源干细胞再生潜力的新兴生物标志物。
Regen Ther. 2024 May 25;26:71-79. doi: 10.1016/j.reth.2024.05.004. eCollection 2024 Jun.
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Human Muse cells isolated from preterm- and term-umbilical cord delivered therapeutic effects in rat bleomycin-induced lung injury model without immunosuppressant.从早产儿和足月产脐带中分离得到的人源 Muse 细胞在没有免疫抑制剂的情况下对博来霉素诱导的大鼠肺损伤模型具有治疗作用。
Stem Cell Res Ther. 2024 May 22;15(1):147. doi: 10.1186/s13287-024-03763-8.
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Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment.供者骨髓间充质干细胞治疗，无需 HLA 配型检测及免疫抑制剂治疗。
Stem Cells Transl Med. 2024 Jun 14;13(6):532-545. doi: 10.1093/stcltm/szae018.