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多谱系分化应激耐受细胞：组织损伤修复的有力工具。

Multilineage-differentiating stress-enduring cells: a powerful tool for tissue damage repair.

作者信息

Que Hanyun, Mai Erziya, Hu Yanting, Li Hong, Zheng Wenxin, Jiang Yuchen, Han Feiruo, Li Xuedong, Gong Puyang, Gu Jian

机构信息

College of Pharmacy, Southwest Minzu University, Chengdu, China.

出版信息

Front Cell Dev Biol. 2024 May 30;12:1380785. doi: 10.3389/fcell.2024.1380785. eCollection 2024.

DOI:10.3389/fcell.2024.1380785
PMID:38872932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11169632/
Abstract

Multilineage-differentiating stress-enduring (Muse) cells are a type of pluripotent cell with unique characteristics such as non-tumorigenic and pluripotent differentiation ability. After homing, Muse cells spontaneously differentiate into tissue component cells and supplement damaged/lost cells to participate in tissue repair. Importantly, Muse cells can survive in injured tissue for an extended period, stabilizing and promoting tissue repair. In addition, it has been confirmed that injection of exogenous Muse cells exerts anti-inflammatory, anti-apoptosis, anti-fibrosis, immunomodulatory, and paracrine protective effects . The discovery of Muse cells is an important breakthrough in the field of regenerative medicine. The article provides a comprehensive review of the characteristics, sources, and potential mechanisms of Muse cells for tissue repair and regeneration. This review serves as a foundation for the further utilization of Muse cells as a key clinical tool in regenerative medicine.

摘要

多谱系分化应激耐受（Muse）细胞是一种具有非致瘤性和多能分化能力等独特特性的多能细胞。归巢后，Muse细胞可自发分化为组织组成细胞，并补充受损/丢失的细胞以参与组织修复。重要的是，Muse细胞能够在损伤组织中长期存活，稳定并促进组织修复。此外，已证实注射外源性Muse细胞具有抗炎、抗凋亡、抗纤维化、免疫调节和旁分泌保护作用。Muse细胞的发现是再生医学领域的一项重要突破。本文全面综述了Muse细胞在组织修复和再生方面的特性、来源及潜在机制。这篇综述为进一步将Muse细胞用作再生医学中的关键临床工具奠定了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a622/11169632/ed4d8acfa765/fcell-12-1380785-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a622/11169632/99e0b86ac163/fcell-12-1380785-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a622/11169632/7ff85e7b1f24/fcell-12-1380785-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a622/11169632/ed4d8acfa765/fcell-12-1380785-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a622/11169632/99e0b86ac163/fcell-12-1380785-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a622/11169632/7ff85e7b1f24/fcell-12-1380785-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a622/11169632/ed4d8acfa765/fcell-12-1380785-g003.jpg

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1
Multilineage-differentiating stress-enduring cells: a powerful tool for tissue damage repair.多谱系分化应激耐受细胞：组织损伤修复的有力工具。
Front Cell Dev Biol. 2024 May 30;12:1380785. doi: 10.3389/fcell.2024.1380785. eCollection 2024.
2
Regenerative potential of pluripotent nontumorgenetic stem cells: Multilineage differentiating stress enduring cells (Muse cells).多能非肿瘤性干细胞的再生潜能：多谱系分化应激耐受细胞（Muse细胞）
Regen Ther. 2020 Jul 27;15:92-96. doi: 10.1016/j.reth.2020.04.011. eCollection 2020 Dec.
3
S1P-S1PR2 Axis Mediates Homing of Muse Cells Into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction.S1P-S1PR2 轴介导 Muse 细胞归巢损伤心脏，实现急性心肌梗死后的持久组织修复和功能恢复。
Circ Res. 2018 Apr 13;122(8):1069-1083. doi: 10.1161/CIRCRESAHA.117.311648. Epub 2018 Feb 23.
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Endogenous reparative pluripotent Muse cells with a unique immune privilege system: Hint at a new strategy for controlling acute and chronic inflammation.具有独特免疫特权系统的内源性修复性多能缪斯细胞：提示控制急慢性炎症的新策略。
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Multilineage-differentiating stress-enduring (Muse)-like cells exist in synovial tissue.多谱系分化应激耐受（Muse）样细胞存在于滑膜组织中。
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Stem Cell Therapy Using Bone Marrow-Derived Muse Cells Repairs Radiation-Induced Intestinal Injury Through Their Intestine-Homing via Sphingosine Monophosphate-Sphingosine Monophosphate Receptor 2 Interaction.使用骨髓来源的多能分化应激耐受细胞的干细胞疗法通过鞘氨醇-1-磷酸-鞘氨醇-1-磷酸受体2相互作用归巢至肠道来修复辐射诱导的肠道损伤。
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Muse Cells Provide the Pluripotency of Mesenchymal Stem Cells: Direct Contribution of Muse Cells to Tissue Regeneration.多能分化应激耐受细胞赋予间充质干细胞多能性：多能分化应激耐受细胞对组织再生的直接贡献。
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Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy.多谱系分化应激耐受（Muse）细胞：基于干细胞治疗的新时代。
Cells. 2023 Jun 21;12(13):1676. doi: 10.3390/cells12131676.
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Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective.多能性非肿瘤性多谱系分化应激耐受细胞（Muse 细胞）：七年回顾。
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Muse cells, newly found non-tumorigenic pluripotent stem cells, reside in human mesenchymal tissues.成体间充质组织中的多潜能干细胞——Muse 细胞。
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本文引用的文献

1
Donor Muse Cell Treatment Without HLA-Matching Tests and Immunosuppressant Treatment.供者骨髓间充质干细胞治疗，无需 HLA 配型检测及免疫抑制剂治疗。
Stem Cells Transl Med. 2024 Jun 14;13(6):532-545. doi: 10.1093/stcltm/szae018.
2
Tumor suppressor let-7 acts as a key regulator for pluripotency gene expression in Muse cells.肿瘤抑制因子 let-7 在 Muse 细胞中作为多能性基因表达的关键调节因子发挥作用。
Cell Mol Life Sci. 2024 Jan 23;81(1):54. doi: 10.1007/s00018-023-05089-9.
3
Randomized placebo-controlled trial of CL2020, an allogenic muse cell-based product, in subacute ischemic stroke.
CL2020 异体间充质干细胞治疗药物治疗急性缺血性脑卒中的随机、安慰剂对照、多中心临床试验
J Cereb Blood Flow Metab. 2023 Dec;43(12):2029-2039. doi: 10.1177/0271678X231202594. Epub 2023 Sep 27.
4
Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy.多谱系分化应激耐受（Muse）细胞：基于干细胞治疗的新时代。
Cells. 2023 Jun 21;12(13):1676. doi: 10.3390/cells12131676.
5
Characterization of early myocardial inflammation in ischemia-reperfusion injury.探讨缺血再灌注损伤早期心肌炎症反应的特点。
Front Immunol. 2023 Feb 6;13:1081719. doi: 10.3389/fimmu.2022.1081719. eCollection 2022.
6
Promoting early neovascularization by allotransplanted adipose-derived Muse cells in an ovine model of acute myocardial infarction.同种异体脂肪来源 Muse 细胞移植促进急性心肌梗死羊模型的早期血管新生。
PLoS One. 2023 Jan 20;18(1):e0277442. doi: 10.1371/journal.pone.0277442. eCollection 2023.
7
Microglia morphophysiological diversity and its implications for the CNS.小胶质细胞形态生理学多样性及其对中枢神经系统的影响。
Front Immunol. 2022 Oct 19;13:997786. doi: 10.3389/fimmu.2022.997786. eCollection 2022.
8
Single-cell RNA sequencing reveals different signatures of mesenchymal stromal cell pluripotent-like and multipotent populations.单细胞RNA测序揭示了间充质基质细胞多能样和多能群体的不同特征。
iScience. 2022 Oct 20;25(11):105395. doi: 10.1016/j.isci.2022.105395. eCollection 2022 Nov 18.
9
Cellular senescence in ischemia/reperfusion injury.缺血/再灌注损伤中的细胞衰老
Cell Death Discov. 2022 Oct 18;8(1):420. doi: 10.1038/s41420-022-01205-z.
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Structural insights into the functional roles of 14-3-3 proteins.对14-3-3蛋白功能作用的结构洞察。
Front Mol Biosci. 2022 Sep 16;9:1016071. doi: 10.3389/fmolb.2022.1016071. eCollection 2022.