Service d'Hématologie, hôpital Saint-Antoine, AP-HP, Sorbonne Université, 75012, Paris, France.
Department of Gastroenterology and Hepatology, Damascus University, Faculty of Medicine, Damascus, Syria.
Curr Res Transl Med. 2020 Aug;68(3):93-104. doi: 10.1016/j.retram.2020.05.004. Epub 2020 May 30.
Since the end of 2019, the COVID-19 pandemic has affected millions of people worldwide. With the rapid spread of this virus, an immense burden has fallen upon both healthcare and economic systems. As a consequence, there is an unprecedented urgency for researchers and scientific committees from all over the world to find an effective treatment and vaccine.
Many potential therapies are currently under investigation, with some, like Hydroxychloroquine, being authorized for emergency use in some countries. The crucial issue is now clearly to find the suitable treatment strategy for patients given comorbidities and the timeline of the illness. Vaccines are also under development and phase 1 clinical trials are rolling. Despite all efforts, no single drug or vaccine has yet been approved. In this review, we aim at presenting the proposed pathophysiological mechanisms of SARS-CoV-2 and to provide clinicians with a brief and solid overview of the current potential treatments classified according to their use at the three different currently proposed disease stages. In light of pathogenesis and proposed clinical classification, this review's purpose is to summarize and simplify the most important updates on the management and the potential treatment of this emergent disease.
自 2019 年底以来，COVID-19 大流行已影响到全球数百万人。随着这种病毒的迅速传播，医疗保健和经济系统都承受着巨大的负担。因此，全世界的研究人员和科学委员会都迫切需要找到有效的治疗方法和疫苗。
目前正在研究许多潜在的疗法，一些疗法，如羟氯喹，已在一些国家获得紧急使用授权。现在的关键问题显然是为患有合并症的患者找到合适的治疗策略，以及疾病的时间进程。疫苗也正在开发中，正在进行 1 期临床试验。尽管做出了所有努力，但尚未批准任何单一药物或疫苗。在本次综述中，我们旨在提出针对 SARS-CoV-2 的拟议病理生理机制，并为临床医生提供当前潜在治疗方法的简要而可靠的概述，这些治疗方法根据其在目前提出的三种不同疾病阶段的用途进行分类。根据发病机制和拟议的临床分类，本综述的目的是总结和简化关于这种紧急疾病的管理和潜在治疗的最重要更新。
