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针对 COVID-19 的 DNA 疫苗：观点与挑战。

DNA vaccines against COVID-19: Perspectives and challenges.

机构信息

Faculty Anhanguera, Department of Pharmacy, Pelotas, Rio Grande do Sul, Brazil.

Institut für Biochemie, Biotechnologie und Bioinformatik, Technische Universität Braunschweig, Braunschweig, Germany.

出版信息

Life Sci. 2021 Feb 15;267:118919. doi: 10.1016/j.lfs.2020.118919. Epub 2020 Dec 19.

DOI:10.1016/j.lfs.2020.118919
PMID:33352173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7749647/
Abstract

The coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is associated with several fatal cases worldwide. The rapid spread of this pathogen and the increasing number of cases highlight the urgent development of vaccines. Among the technologies available for vaccine development, DNA vaccination is a promising alternative to conventional vaccines. Since its discovery in the 1990s, it has been of great interest because of its ability to elicit both humoral and cellular immune responses while showing relevant advantages regarding producibility, stability, and storage. This review aimed to summarize the current knowledge and advancements on DNA vaccines against COVID-19, particularly those in clinical trials.

摘要

新型冠状病毒病（COVID-19）由一种新型冠状病毒引起，称为严重急性呼吸系统综合症冠状病毒 2（SARS-CoV-2），该病毒在全球范围内导致了多例致命病例。这种病原体的迅速传播和病例的不断增加凸显了疫苗紧急开发的必要性。在现有的疫苗开发技术中，DNA 疫苗是传统疫苗的一种有前途的替代品。自 20 世纪 90 年代发现以来，由于其能够引发体液和细胞免疫反应，并且在可生产性、稳定性和存储方面具有相关优势，因此引起了极大的关注。本综述旨在总结针对 COVID-19 的 DNA 疫苗的现有知识和进展，特别是那些处于临床试验阶段的疫苗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1663/7749647/53c7e5e19ce4/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1663/7749647/a1040b67cde6/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1663/7749647/53c7e5e19ce4/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1663/7749647/a1040b67cde6/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1663/7749647/53c7e5e19ce4/gr1_lrg.jpg

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[4]
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[5]
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Adv Exp Med Biol. 2024

[6]
COVID-19: vaccination, therapeutics and a review of the science and public health.

Ann Med Surg (Lond). 2024-7-17

[7]
Enhancing Immune Responses against SARS-CoV-2 Variants in Aged Mice with INDUK: A Chimeric DNA Vaccine Encoding the Spike S1-TM Subunits.

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[8]
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[9]
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Curr Microbiol. 2024-7-20

[10]
Immunogenicity and protection efficacy of a COVID-19 DNA vaccine encoding spike protein with D614G mutation and optimization of large-scale DNA vaccine production.

Sci Rep. 2024-6-15

本文引用的文献

[1]
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[2]
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Life Sci. 2020-9-9

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Coronavirus Disease 2019 (COVID-19) Re-infection by a Phylogenetically Distinct Severe Acute Respiratory Syndrome Coronavirus 2 Strain Confirmed by Whole Genome Sequencing.

Clin Infect Dis. 2021-11-2

[10]
COVID-19 Vaccines: A Race Against Time in the Middle of Death and Devastation!

J Clin Exp Hepatol. 2020

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