Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Can J Physiol Pharmacol. 2020 Aug;98(8):483-489. doi: 10.1139/cjpp-2020-0286. Epub 2020 Jul 8.
In response to the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), researchers are expeditiously searching for antiviral treatments able to alleviate the symptoms of infection, which can be life-threatening. Here, we provide a general overview of what is currently known about the structure and characteristic features of SARS-CoV-2, some of which could potentially be exploited for the purposes of antiviral therapy and vaccine development. This minireview also covers selected and noteworthy antiviral agents/supportive therapy out of hundreds of drugs that are being repurposed or tested as potential treatments for COVID-19, the disease caused by SARS-CoV-2.
针对严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的爆发，研究人员正在迅速寻找能够缓解感染症状的抗病毒治疗方法，因为这些症状可能危及生命。在这里，我们提供了一个关于 SARS-CoV-2 的结构和特征的概述，其中一些可能有潜力被用于抗病毒治疗和疫苗开发。这篇简评还涵盖了作为 SARS-CoV-2 引起的 COVID-19 的潜在治疗方法而被重新利用或测试的数百种药物中选择的、值得注意的抗病毒药物/支持性疗法。
