Mehra Aseem, Suri Vikas, Kumari Savita, Avasthi Ajit, Grover Sandeep
Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Asian J Psychiatr. 2020 Oct;53:102185. doi: 10.1016/j.ajp.2020.102185. Epub 2020 May 30.
The aim of this study was to evaluate the prevalence of mild cognitive impairment (MCI) in patients with hypertension and to evaluate the association of MCI with metabolic syndrome (MetS).
186 subjects with hypertension were evaluated on Montreal Cognitive Assessment (MoCA) and Patient Health Questionnaire (PHQ-9) for cognitive decline and depression, respectively and MetS was diagnosed as per the Consensus definition.
The prevalence of MCI was 65.6 % and that of MetS was 45.7 %. Compared to those without MetS, those with MetS had significantly poorer cognitive functioning on the all cognitive domain of the MoCA, even after controlling for age, education, severity of the depression and duration of illness. Low High-Density Lipoprotein (HDL) was found to have a positive correlation with MoCA. Higher age, lower education, higher duration of illness and use of higher numbers of medications were associated with significantly lower score on MoCA.
Presence of MetS among persons with hypertension is associated with cognitive decline. Hence, there is a need to monitor and manage other parameters of MetS among patients with hypertension, to reduce the risk of cognitive decline and future dementia.
本研究旨在评估高血压患者轻度认知障碍（MCI）的患病率，并评估MCI与代谢综合征（MetS）之间的关联。
对186名高血压患者分别进行蒙特利尔认知评估（MoCA）和患者健康问卷（PHQ-9）以评估认知功能下降和抑郁情况，并根据共识定义诊断MetS。
MCI的患病率为65.6%，MetS的患病率为45.7%。与无MetS的患者相比，即使在控制了年龄、教育程度、抑郁严重程度和病程后，有MetS的患者在MoCA的所有认知领域的认知功能仍显著较差。发现低高密度脂蛋白（HDL）与MoCA呈正相关。年龄较大、教育程度较低、病程较长以及使用较多药物与MoCA得分显著较低相关。
高血压患者中MetS的存在与认知功能下降有关。因此，有必要对高血压患者的MetS其他参数进行监测和管理，以降低认知功能下降和未来患痴呆症的风险。
