Zhai Cui, Li Shaojun, Feng Wei, Shi Wenhua, Wang Jian, Wang Qingting, Chai Limin, Zhang Qianqian, Yan Xin, Li Manxiang
Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, China.
Arch Med Sci. 2018 Oct;14(6):1204-1211. doi: 10.5114/aoms.2018.73345. Epub 2018 Mar 2.
Interleukin-17A (IL-17A), a pro-inflammatory cytokine, plays an important role in the pathogenesis of asthma. A number of studies have investigated the relationship between IL-17A rs2275913 polymorphism and risk of asthma. However, the results obtained are inconclusive. The aim of this meta-analysis is to clarify the relationship between IL-17A rs2275913 polymorphism and asthma risk.
Searches were conducted in PubMed, Web of Science, Elsevier, Google Scholar, Wanfang and Chinese National Knowledge Infrastructure (CNKI) databases, and data were extracted from eligible studies by two independent reviewers. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated. Publication bias, heterogeneity and sensitivity analysis were also assessed.
Ten studies with a total of 5016 subjects were included. Overall, the results indicated a significant association between the IL-17A rs2275913 polymorphism and the risk of asthma (G vs. A: OR = 0.866, 95% CI: 0.789-0.951, = 0.003; GG+GA vs. AA: OR = 0.752, 95% CI: 0.633-0.895, = 0.001). In subgroup analysis by age and ethnicity, the G allele of rs2275913 in IL-17A was significantly associated with a reduced risk of asthma in children and Asians.
The results of this meta-analysis indicate that the G allele of rs2275913 in IL-17A is a protective factor for the development of asthma.
白细胞介素 - 17A（IL - 17A）是一种促炎细胞因子，在哮喘发病机制中起重要作用。许多研究调查了IL - 17A rs2275913多态性与哮喘风险之间的关系。然而，所得结果尚无定论。本荟萃分析的目的是阐明IL - 17A rs2275913多态性与哮喘风险之间的关系。
在PubMed、Web of Science、Elsevier、谷歌学术、万方和中国知网（CNKI）数据库中进行检索，由两名独立评审员从符合条件的研究中提取数据。计算合并优势比（OR）和相应的95%置信区间（CI）。还评估了发表偏倚、异质性和敏感性分析。
纳入了10项研究，共5016名受试者。总体而言，结果表明IL - 17A rs2275913多态性与哮喘风险之间存在显著关联（G对A：OR = 0.866，95%CI：0.789 - 0.951，P = 0.003；GG + GA对AA：OR = 0.752，95%CI：0.633 - 0.895，P = 0.001）。在按年龄和种族进行的亚组分析中，IL - 17A中rs2275913的G等位基因与儿童和亚洲人哮喘风险降低显著相关。
本荟萃分析结果表明，IL - 17A中rs2275913的G等位基因是哮喘发生发展的保护因素。
Zotero 插件
