Department of Urology, Princess Alexandra Hospital, University of Queensland, Brisbane, Qld, Australia.
Andro Urology Centre, Brisbane, Qld, Australia.
BJU Int. 2020 Sep;126 Suppl 1:12-17. doi: 10.1111/bju.15057. Epub 2020 Jun 16.
To provide a clinical framework and key guideline statements to assist clinicians in the evidence-based management of Peyronie's disease (PD).
We conducted a review of the published literature relevant to PD management, with an emphasis on published clinical guidelines. References used in the text have been assessed according to their level of evidence, and guideline recommendations have been graded based on the Oxford Centre for Evidence-based Medicine Levels of Evidence.
The management of PD involves taking a detailed penile and sexual history, with a focused penile examination to identify plaque and hourglass deformity, and digital photographs of the erect curved (deformed) penis. Penile colour Duplex ultrasonography evaluates tunical plaque and underlying cavernosal smooth muscle and blood flow variables. The current therapy for PD can be divided into two main groups, namely, medical therapy and penile reconstructive surgery, and the patient should be counselled on the benefits and risks of each treatment option.
Peyronie's disease remains a clinical challenge and presents a considerable therapeutic dilemma as the current therapy addresses existing penile curvature only and is not very effective in preventing future penile fibrosis and/or reversing underlying erectile dysfunction.
为临床医生提供一个临床框架和关键指南声明，以帮助他们对 Peyronie 病（PD）进行循证管理。
我们对与 PD 管理相关的已发表文献进行了综述，重点是已发表的临床指南。本文中使用的参考文献根据其证据水平进行了评估，并且根据牛津循证医学中心的证据水平对指南建议进行了分级。
PD 的管理涉及详细的阴茎和性病史，以及对斑块和沙漏畸形的集中阴茎检查，并对勃起弯曲（变形）阴茎进行数字照片拍摄。阴茎彩色双功能超声评估了白膜斑块和潜在的海绵体平滑肌以及血流变量。PD 的当前治疗方法可分为两大类，即药物治疗和阴茎重建手术，应向患者介绍每种治疗选择的益处和风险。
Peyronie 病仍然是一个临床挑战，并且存在相当大的治疗困境，因为目前的治疗方法仅针对现有的阴茎弯曲，并且在预防未来的阴茎纤维化和/或逆转潜在的勃起功能障碍方面效果并不十分理想。
