Department of Toxicology, Faculty of Health Sciences, University of Lome, Lome, Togo.
Department of Animal Physiology and Pharmacology, Faculty of Sciences, University of Lome, Lome, Togo.
J Med Food. 2020 Dec;23(12):1323-1327. doi: 10.1089/jmf.2019.0221. Epub 2020 Jun 16.
(Asteraceae) is a widely used vegetable in West Africa. It is used in traditional healing of many diseases such as hypertension, anemia, diabetes, and bleeding. The aim of this study is to investigate the cytotoxicity and the acute and subacute (28 days) oral toxicity of hydroethanolic leaves extract on male Wistar rats. The LC values of on brine shrimp were 0.142 ± 0.11 mg/mL. The limit test dose of 5000 mg/kg did not provoke death or toxicity signs in the rats tested during the observation period. For 28 days subacute toxicity at 500 and 1000 mg/kg body weight, no signs of toxicity or mortality were observed during the experiment. There was no significant difference between the treated groups and the control group concerning the body and the relative organs weight ( > .05). Results of biochemical and hematological parameters did not show any treatment-related abnormalities. According to our results, the hydroethanolic extract of leaves, at 500 and 1000 mg/kg body weight, is safe when administrated to male Wistar rats for 28 days.
（菊科）是西非广泛使用的蔬菜。它用于治疗许多疾病，如高血压、贫血、糖尿病和出血等传统疗法。本研究旨在研究水醇提叶提取物对雄性 Wistar 大鼠的细胞毒性以及急性和亚急性（28 天）口服毒性。对卤虫的 LC 值为 0.142±0.11mg/mL。在观察期内，测试的大鼠中，5000mg/kg 的极限测试剂量没有引起死亡或毒性迹象。在为期 28 天的亚急性毒性试验中，以 500 和 1000mg/kg 体重给予受试物，实验过程中未观察到毒性或死亡率。与对照组相比，各处理组的体重和相对器官重量均无显著差异（>0.05）。生化和血液学参数的结果未显示任何与治疗相关的异常。根据我们的结果，水醇提 叶提取物，以 500 和 1000mg/kg 体重给予雄性 Wistar 大鼠，28 天内是安全的。
