Adinortey Michael Buenor, Sarfo Justice Kwabena, Kwarteng Jeffery, Adinortey Cynthia Ayefoumi, Ekloh William, Kuatsienu Lydia Enyonam, Kwadwo Nyarko Alexander
Department of Biochemistry, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.
Department of Molecular Biology and Biotechnology, School of Biological Sciences, College of Agriculture and Natural Sciences, University of Cape Coast, Cape Coast, Ghana.
Evid Based Complement Alternat Med. 2018 Jul 25;2018:7259146. doi: 10.1155/2018/7259146. eCollection 2018.
(Willd.) Amin ex C. Jeffrey is a herb found mostly in tropical Africa. The plant, commonly found in West Africa, is used in the management of many diseases including cardiovascular, respiratory, haematological, endocrine, and metabolic diseases in Ghana, Nigeria, Benin, Serra Leone, and Senegal. This piece provides comprehensive and updated information on the traditional uses, phytochemical constituents, and pharmacological and toxicological information available on to support its medicinal uses and also unearth knowledge gaps for future studies. An electronic literature search using search engines, namely, Google Scholar, ScienceDirect, and PubMed, was carried out to obtain information on the plant. Both common and scientific names of the plant were used as keywords for the search process. This paper captured information on from 1985 to 2018. The search revealed that the leaves of the plant possess nutritional/pharmacological effects on diseases such as diabetes mellitus, hypertension, cancer, malaria, bacterial infections, and arthritis. The leaf has been shown to be a rich source of phytoconstituents such as flavonoids, phenolic acids, tannins, alkaloids, glycosides, coumarins, triterpenoids, ascorbic acid, lycopene, and -carotene. Also, isolated phytoconstituents as well as the safety profile of the plant have been documented. This review on has provided a one-stop documentation of information in support of the several purported ethnopharmacological uses of the plant. It also reveals information gaps such as the need to research into its pharmacokinetics, interactions with drugs of importance, and its development into a plant-based drug in order to expand its clinical use.
(威尔德)阿明经C.杰弗里鉴定的这种草本植物主要生长在热带非洲。这种植物常见于西非，在加纳、尼日利亚、贝宁、塞拉利昂和塞内加尔被用于治疗多种疾病，包括心血管疾病、呼吸系统疾病、血液学疾病、内分泌疾病和代谢疾病。本文提供了关于该植物传统用途、植物化学成分以及现有药理和毒理学信息的全面且最新的内容，以支持其药用，并揭示未来研究的知识空白。通过使用搜索引擎谷歌学术、ScienceDirect和PubMed进行电子文献检索，以获取有关该植物的信息。植物的通用名和学名均用作检索关键词。本文收集了1985年至2018年关于该植物的信息。检索发现该植物的叶子对糖尿病、高血压、癌症、疟疾、细菌感染和关节炎等疾病具有营养/药理作用。已证明叶子富含黄酮类化合物、酚酸、单宁、生物碱、糖苷、香豆素、三萜类化合物、抗坏血酸、番茄红素和β-胡萝卜素等植物成分。此外，还记录了分离出的植物成分以及该植物的安全性概况。这篇关于该植物的综述提供了一站式信息记录，以支持该植物多种所谓的民族药理学用途。它还揭示了信息空白，例如需要研究其药代动力学、与重要药物的相互作用以及将其开发成植物性药物以扩大其临床应用。
