智利Q热和立克次体病的证据。
Evidence of Q Fever and Rickettsial Disease in Chile.
作者信息
Tapia Teresa, Stenos John, Flores Roberto, Duery Oscar, Iglesias Rodrigo, Olivares Maria Fernanda, Gallegos Doris, Rosas Cristian, Wood Heidi, Acevedo Johanna, Araya Pamela, Graves Stephen R, Hormazabal Juan Carlos
机构信息
Bacteriology, Sub-Department of Infectious Diseases, Department Biomedical Laboratory, Public Health Institute of Chile, Santiago 7780050, Chile.
Australian Rickettsial Reference Laboratory, Barwon Health, Geelong, VIC 3220, Australia.
出版信息
Trop Med Infect Dis. 2020 Jun 11;5(2):99. doi: 10.3390/tropicalmed5020099.
Q fever and rickettsial diseases occur throughout the world and appear to be emergent zoonoses in Chile. The diagnosis of these diseases is currently uncommon in Chile, as their clinical presentations are non-specific and appropriate diagnostic laboratory assays are of limited availability. During a recent outbreak of undiagnosed human atypical pneumonia, we serologically investigated a series of 357 cases from three regions of southern Chile. The aim was to identify those caused by and/or spp. Serological analysis was performed by ELISA and an immunofluorescence assay (IFA) for acute and convalescence sera of patients. Our results, including data from two international reference laboratories, demonstrate that 71 (20%) of the cases were Q fever, and 44 (15%) were a likely rickettsial infection, although the rickettsial species could not be confirmed by serology. This study is the first report of endemic Q fever and rickettsial disease affecting humans in Chile.
Q热和立克次体病在全球范围内均有发生，在智利似乎是新出现的人畜共患病。目前，这些疾病在智利的诊断并不常见，因为它们的临床表现不具有特异性，且可用的适当诊断实验室检测方法有限。在最近一次未确诊的人类非典型肺炎疫情期间，我们对来自智利南部三个地区的357例病例进行了血清学调查。目的是确定由 和/或 属引起的病例。通过ELISA和免疫荧光试验（IFA）对患者的急性期和恢复期血清进行血清学分析。我们的结果，包括来自两个国际参考实验室的数据，表明71例（20%）病例为Q热，44例（15%）可能为立克次体感染，尽管血清学无法确诊立克次体种类。本研究是智利首次报告影响人类的地方性Q热和立克次体病。
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