Phytotechnics Laboratory, Universidade Estadual do Norte Fluminense Darcy Ribeiro-UENF, Campos dos Goytacazes, RJ 28013-602, Brazil.
Molecular Markers Laboratory, IRCCS Instituto Centro San Giovanni di Dio Fatebenefrate lli, 25125 Brescia, Italy.
Biomolecules. 2020 Jun 12;10(6):897. doi: 10.3390/biom10060897.
Copper is an essential nutrient for plants, animals, and humans because it is an indispensable component of several essential proteins and either lack or excess are harmful to human health. Recent studies revealed that the breakdown of the regulation of copper homeostasis could be associated with Alzheimer's disease (AD), the most common form of dementia. Copper accumulation occurs in human aging and is thought to increase the risk of AD for individuals with a susceptibility to copper exposure. This review reports that one of the leading causes of copper accumulation in the environment and the human food chain is its use in agriculture as a plant protection product against numerous diseases, especially in organic production. In the past two decades, some countries and the EU have invested in research to reduce the reliance on copper. However, no single alternative able to replace copper has been identified. We suggest that agroecological approaches are urgently needed to design crop protection strategies based on the complementary actions of the wide variety of crop protection tools for disease control.
铜是植物、动物和人类必需的营养物质，因为它是几种必需蛋白质的不可或缺的组成部分，无论是缺乏还是过量都会对人类健康有害。最近的研究表明，铜稳态调节的破坏可能与阿尔茨海默病（AD）有关，AD 是痴呆症最常见的形式。铜在人体衰老过程中积累，并且据认为会增加易受铜暴露影响的个体患 AD 的风险。本综述报告称，在环境和人类食物链中导致铜积累的主要原因之一是将其作为一种植物保护产品用于农业，以防治多种疾病，尤其是在有机生产中。在过去的二十年中，一些国家和欧盟已经投资于研究以减少对铜的依赖。然而，尚未发现能够替代铜的单一替代品。我们建议迫切需要采用农业生态方法，根据各种作物保护工具在控制疾病方面的互补作用，设计作物保护策略。
