Nguyen Thao T, Bergeron Erica, Lewis Teresa V, Miller Jamie L, Hagemann Tracy M, Neely Stephen, Johnson Peter N
The Children's Hospital at Saint Francis, Tulsa, OK, USA.
Department of Pharmacy: Clinical and Administrative Sciences, The University of Oklahoma College of Pharmacy, Oklahoma City, OK, USA.
SAGE Open Med. 2020 Jun 3;8:2050312120927945. doi: 10.1177/2050312120927945. eCollection 2020.
Limited studies have evaluated medications in children discharged from hospitals. Knowledge of the number of medications and dosage forms could provide a baseline to establish a medication discharge prescription program.
To identify the median number of discharge prescriptions per patient. Secondary objectives included an evaluation of the dosage formulations and frequency, and comparisons of the prevalence of unrounded medication doses between service type (medical vs surgical) and physician provider level (trainees vs attendings).
This retrospective study included children <18 years receiving >1 discharge prescription during 4 selected months over a 1-year time frame. Comparisons were made via Pearson's chi-square tests, Fisher's Exact tests, and Kruskal-Wallis nonparametric rank tests as appropriate with a priori value of <0.05.
A total of 852 patients were evaluated, with most (78.8%) on a medical service. The median (interquartile range) number of new medications at discharge was 2 (1-3), with the median total number of discharge medications of 3 (2-6). There was no difference in the net change of the median number of home medications stopped and new medications started between service types. The majority (72.2%) received >1 oral liquid medications. There was no difference in prescribing rates per service type and provider level. There was a difference in the number of unrounded doses between trainees versus attendings, 17.8% versus 9.5%, = 0.048.
Patients were discharged on a median of three medications, and most received >1 oral liquid medications. These data can be used to target children who would benefit from medication discharge prescription programs.
对出院儿童用药情况进行评估的研究有限。了解用药数量和剂型可为建立出院用药处方计划提供基线数据。
确定每位患者出院处方的中位数。次要目标包括评估剂型和用药频率，以及比较不同服务类型（内科与外科）和医生级别（实习医生与主治医生）之间非整数剂量用药的发生率。
这项回顾性研究纳入了在1年时间内4个选定月份中接受超过1张出院处方的18岁以下儿童。根据情况，通过Pearson卡方检验、Fisher精确检验和Kruskal-Wallis非参数秩和检验进行比较，先验值<0.05。
共评估了852例患者，其中大多数（78.8%）在内科接受治疗。出院时新用药的中位数（四分位间距）为2（1 - 3），出院用药总数的中位数为3（2 - 6）。不同服务类型之间，停用的家庭用药中位数和新开的用药中位数的净变化无差异。大多数（72.2%）患者接受了超过1种口服液体制剂。不同服务类型和医生级别之间的处方率无差异。实习医生与主治医生之间非整数剂量的数量存在差异，分别为17.8%和9.5%，P = 0.048。
患者出院时平均使用三种药物，大多数患者接受了超过1种口服液体制剂。这些数据可用于确定那些将从出院用药处方计划中受益的儿童。
