Mwangi William, Maccari Giuseppe, Hope Jayne C, Entrican Gary, Hammond John A
The Pirbright Institute, Woking, UK.
Royal Free Hospital, Anthony Nolan Research Institute, London, UK.
Immunology. 2020 Sep;161(1):25-27. doi: 10.1111/imm.13227. Epub 2020 Jul 29.
Using the best animal models to study immune responses against specific pathogens or vaccines can dramatically accelerate our understanding. Veterinary species are well studied, particularly livestock, to reduce their disease burden. They have also proven to be powerful models, especially for zoonotic pathogens and novel vaccination strategies. A prerequisite for any model selection is having the right quality and range of species-specific immunological reagents. To help promote the widest possible use of veterinary species, an open access website (https://www.immunologicaltoolbox.co.uk) has been created as a central community annotated hub for veterinary immunological reagents. The website is also the portal into services offered by the UK Immunological Toolbox project that includes antibody generation, sequencing and recombinant expression. The funding for this effort is linked into sustainable sources, but ultimate success relies on community engagement to continually increase the quality and quantity of information. It is hoped that as more users and reagent owners engage, it will become an essential resource for researchers, veterinarians and clinicians alike by removing barriers that prevent the use of the most informative animal models.
使用最佳动物模型来研究针对特定病原体或疫苗的免疫反应能够极大地加速我们的理解。兽医物种,尤其是家畜,已经得到了充分研究,以减轻它们的疾病负担。它们也已被证明是强大的模型,特别是对于人畜共患病原体和新型疫苗接种策略。任何模型选择的一个先决条件是拥有合适质量和种类的物种特异性免疫试剂。为了帮助促进兽医物种的尽可能广泛使用,一个开放获取网站(https://www.immunologicaltoolbox.co.uk)已被创建,作为兽医免疫试剂的中央社区注释中心。该网站也是进入英国免疫工具箱项目所提供服务的门户,这些服务包括抗体生成、测序和重组表达。这项工作的资金与可持续来源相关联,但最终的成功依赖于社区参与,以不断提高信息的质量和数量。希望随着越来越多的用户和试剂所有者参与进来,它将通过消除阻碍使用最具信息性动物模型的障碍,成为研究人员、兽医和临床医生不可或缺的资源。