Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Nat Rev Immunol. 2021 Dec;21(12):815-822. doi: 10.1038/s41577-021-00567-2. Epub 2021 Jun 17.
Since the initial use of vaccination in the eighteenth century, our understanding of human and animal immunology has greatly advanced and a wide range of vaccine technologies and delivery systems have been developed. The COVID-19 pandemic response leveraged these innovations to enable rapid development of candidate vaccines within weeks of the viral genetic sequence being made available. The development of vaccines to tackle emerging infectious diseases is a priority for the World Health Organization and other global entities. More than 70% of emerging infectious diseases are acquired from animals, with some causing illness and death in both humans and the respective animal host. Yet the study of critical host-pathogen interactions and the underlying immune mechanisms to inform the development of vaccines for their control is traditionally done in medical and veterinary immunology 'silos'. In this Perspective, we highlight a 'One Health vaccinology' approach and discuss some key areas of synergy in human and veterinary vaccinology that could be exploited to accelerate the development of effective vaccines against these shared health threats.
自 18 世纪首次使用疫苗以来，我们对人类和动物免疫学的理解有了很大的进步，并且开发了多种疫苗技术和输送系统。在 COVID-19 大流行期间，这些创新被利用起来，使得在获得病毒遗传序列的几周内就可以快速开发候选疫苗。应对新出现的传染病的疫苗开发是世界卫生组织和其他全球实体的优先事项。超过 70%的新发传染病是从动物身上获得的，其中一些会在人类和相应的动物宿主中引起疾病和死亡。然而，为控制这些传染病而研究关键的宿主-病原体相互作用和潜在的免疫机制，传统上是在医学和兽医免疫学的“筒仓”中进行的。在本观点中，我们强调了一种“同一健康疫苗学”方法，并讨论了人类和兽医疫苗学中可以利用的一些协同关键领域，以加速开发针对这些共同健康威胁的有效疫苗。
