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mRNA splicing is attenuated under prolonged exposure to ER stress.

作者信息

Tsialikas Jennifer, Argon Yair

机构信息

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104.

出版信息

MicroPubl Biol. 2017 Oct 12;2017. doi: 10.17912/W2707X.

DOI:10.17912/W2707X
PMID:32550360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7255880/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3838/7255880/ee24a931174e/25789430-2017-W2707X.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3838/7255880/ee24a931174e/25789430-2017-W2707X.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3838/7255880/ee24a931174e/25789430-2017-W2707X.jpg

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XBP-1, a key regulator of unfolded protein response, activates transcription of IGF1 and Akt phosphorylation in zebrafish embryonic cell line.XBP-1是未折叠蛋白反应的关键调节因子,可激活斑马鱼胚胎细胞系中IGF1的转录和Akt磷酸化。
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本文引用的文献

1
Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent association.蛋白二硫键异构酶 A6 通过二硫键依赖的结合控制 IRE1α 信号的衰减。
Mol Cell. 2014 Feb 20;53(4):562-576. doi: 10.1016/j.molcel.2014.01.004. Epub 2014 Feb 6.
2
IRE1 signaling affects cell fate during the unfolded protein response.肌醇需求酶1(IRE1)信号通路在未折叠蛋白反应过程中影响细胞命运。
Science. 2007 Nov 9;318(5852):944-9. doi: 10.1126/science.1146361.
3
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.
肌醇需求酶1(IRE1)通过加工XBP-1信使核糖核酸(mRNA),将内质网负荷与分泌能力联系起来。
Nature. 2002 Jan 3;415(6867):92-6. doi: 10.1038/415092a.
4
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.互补信号通路调节未折叠蛋白反应,是秀丽隐杆线虫发育所必需的。
Cell. 2001 Dec 28;107(7):893-903. doi: 10.1016/s0092-8674(01)00612-2.