Davis T Zane, Green Benedict T, Stegelmeier Bryan L, Lee Stephen T
U.S. Department of Agriculture-Agricultural Research Service, Poisonous Plant Research Laboratory, Logan, UT, USA.
Toxicon X. 2020 Jan 2;5:100022. doi: 10.1016/j.toxcx.2019.100022. eCollection 2020 Mar.
and are toxic plants that contain the putative toxin tremetone. It is common for to poison livestock in the southwestern United States. has been suspected of poisoning livestock but its toxicity has not been confirmed by association with clinical poisonings or experimental studies. Jersey calves dosed with and for nine days developed "trembles" characterized by skeletal muscle degeneration and necrosis and large increases in serum creatine kinase activity. This is the first report of toxicity in an animal model. This study also demonstrates that remains toxic even though tremetone concentrations in the plant were low due to storage of the plant for over five years. Thus, supporting recent research which indicates that another toxin in the plant may be responsible for, or at least contributes to causing "trembles" in livestock.
[植物名称1]和[植物名称2]是含有假定毒素震颤酮的有毒植物。在美国西南部，[植物名称1]致使牲畜中毒的情况很常见。[植物名称2]曾被怀疑会使牲畜中毒，但尚未通过与临床中毒案例或实验研究关联来证实其毒性。给泽西小牛投喂[植物名称1]和[植物名称2]九天后，小牛出现了以骨骼肌变性和坏死以及血清肌酸激酶活性大幅升高为特征的“颤抖病”。这是动物模型中关于[植物名称2]毒性的首次报告。该研究还表明，尽管由于植物储存了五年多，其体内震颤酮浓度较低，但[植物名称2]仍具有毒性。因此，这支持了最近的研究，即该植物中的另一种毒素可能是导致或至少促成牲畜“颤抖病”的原因。
