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COVID-19 患者的治疗和研究方向。我们有什么,我们要去哪里?

Treatment and research lines for the patient with COVID-19. What do we have and where are we going?

机构信息

Servicio de Neumología, IIS-Fundación Jiménez Díaz - ISCIII-CIBERES, Madrid, Spain.

出版信息

Int Braz J Urol. 2020 Jul;46(suppl.1):125-132. doi: 10.1590/S1677-5538.IBJU.2020.S118.

DOI:10.1590/S1677-5538.IBJU.2020.S118
PMID:32550705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7720001/
Abstract

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) represents the most significant global public health crisis of this generation. From the beginning of the pandemic, several publications and on-line resources about different treatment lines have been done, and development effort in response to the COVID-19 pandemic to investigate potential therapies is unprecedented. Unfortunately, until now, there is not enough evidence to recommend any specific anti-COVID19 treatment. Randomized clinical trials and high-quality evidence, even in the middle of a pandemic, are needed. We provide a review of the latest published literature on the therapeutic strategies and current investigational lines for SARS-CoV-2.

摘要

由严重急性呼吸系统综合症冠状病毒 2 型(SARS-CoV-2)引起的 2019 年冠状病毒病(COVID-19)是这一代人面临的最重大的全球公共卫生危机。从疫情开始,就已经有关于不同治疗方案的出版物和在线资源,针对 COVID-19 疫情开展的调查潜在疗法的工作力度也是空前的。不幸的是,到目前为止,还没有足够的证据推荐任何特定的抗 COVID-19 治疗方法。即使在大流行期间,也需要随机临床试验和高质量的证据。我们回顾了关于 SARS-CoV-2 的治疗策略和当前研究方向的最新已发表文献。

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本文引用的文献

1
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.严重急性呼吸综合征冠状病毒2(SARS-CoV-2)进入因子与固有免疫基因一起在鼻上皮细胞中高表达。
Nat Med. 2020 May;26(5):681-687. doi: 10.1038/s41591-020-0868-6. Epub 2020 Apr 23.
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The pathogenesis and treatment of the `Cytokine Storm' in COVID-19.新型冠状病毒病中“细胞因子风暴”的发病机制与治疗。
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The possible of immunotherapy for COVID-19: A systematic review.免疫疗法治疗 COVID-19 的可能性:系统评价。
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Treating COVID-19 with Chloroquine.用氯喹治疗新型冠状病毒肺炎。
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8
COVID-19: Melatonin as a potential adjuvant treatment.新型冠状病毒肺炎:褪黑素作为一种潜在的辅助治疗方法。
Life Sci. 2020 Jun 1;250:117583. doi: 10.1016/j.lfs.2020.117583. Epub 2020 Mar 23.
9
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.羟氯喹和阿奇霉素治疗 COVID-19:一项开放标签非随机临床试验的结果。
Int J Antimicrob Agents. 2020 Jul;56(1):105949. doi: 10.1016/j.ijantimicag.2020.105949. Epub 2020 Mar 20.
10
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2.基于网络的2019新型冠状病毒(2019-nCoV/SARS-CoV-2)药物重新利用研究
Cell Discov. 2020 Mar 16;6:14. doi: 10.1038/s41421-020-0153-3. eCollection 2020.