Baindara Piyush, Agrawal Sonali, Mandal Santi M
Department of Molecular Microbiology and Immunology, University of Missouri , Columbia, MO, USA.
Immunology Division, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases , Agra, India.
Expert Opin Biol Ther. 2020 Oct;20(10):1117-1120. doi: 10.1080/14712598.2020.1807001. Epub 2020 Aug 12.
Coronavirus disease 2019 (COVID-19) characterized by immuno-pathological host responses including pneumonia, lymphopenia, and cytokine storm that leads to severe lung inflammation, developed in acute respiratory distress syndrome (ARDS). In the absence of an effective vaccine or any definitive cure, the use of host-directed therapies is an effective alternative and demanding treatment option in the current pandemic outbreak of COVID-19.
2019冠状病毒病（COVID-19）的特征是免疫病理宿主反应，包括肺炎、淋巴细胞减少和细胞因子风暴，这些反应会导致严重的肺部炎症，并发展为急性呼吸窘迫综合征（ARDS）。在缺乏有效疫苗或明确治愈方法的情况下，使用宿主导向疗法是当前COVID-19大流行爆发中一种有效的替代和急需的治疗选择。
