Algin Demet İlhan, Erdinç Oğuz Osman
Department of Neurology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Turkey.
Noro Psikiyatr Ars. 2018 Apr 20;57(2):108-112. doi: 10.29399/npa.23047. eCollection 2020 Jun.
In this study, our goal was to analyze further the cortical excitability levels in idiopathic generalized epilepsy (IGE) patients with and without photosensitivity.
Forty-two patients (16 men and 26 women; mean age 30±8 years; range: 18-43 years) with IGE and thirty healthy age-matched control subjects (15 men and 15 women; mean age 35±3 years; range: 20-45 years) were enrolled for the investigation. We investigated the following two groups: 18 subjects with IGE with photosensitivity (IGE+PS), and 24 patients with IGE without photosensitivity (IGE-PS). Pattern reversal and potential inter-peak amplitudes, N75-P100 and P100-N145, as well as the corresponding latencies (N75, P100, and N145) for one hundred responses were measured 6 times. A linear regression slope was used for N75-P100 and P100-N145.
Statistical analysis showed difference between groups where the IGE+PS had reduced N75-P100 compared to IGE-PS and controls. In IGE+PS group, the amplitude of N75-P100 was drastically reduced receiving antiepileptic therapy compared to those not receiving any anti-epileptic treatment (p=0.035).
These results show that the IGE+PS group has a different photoparoxysmal response phenotype driven by an unknown and distinct molecular mechanism. Pre-activation cortical excitability may be increased in IGE+PS patients compared to the IGE-PS or in healthy group. PR-VEP habituation may project the pathophysiological mechanisms underlying photosensitivity and it may be potential biomarker in patients with IGE+PS.
在本研究中，我们的目标是进一步分析有和没有光敏性的特发性全身性癫痫（IGE）患者的皮质兴奋性水平。
招募了42例IGE患者（16名男性和26名女性；平均年龄30±8岁；范围：18 - 43岁）和30名年龄匹配的健康对照者（15名男性和15名女性；平均年龄35±3岁；范围：20 - 45岁）进行调查。我们研究了以下两组：18例有光敏性的IGE患者（IGE + PS）和24例无光敏性的IGE患者（IGE - PS）。对100次反应测量了模式反转和峰间电位振幅，即N75 - P100和P100 - N145，以及相应的潜伏期（N75、P100和N145），共测量6次。对N75 - P100和P100 - N145使用线性回归斜率。
统计分析显示各群组之间存在差异，与IGE - PS组和对照组相比，IGE + PS组的N75 - P100降低。在IGE + PS组中，与未接受任何抗癫痫治疗的患者相比，接受抗癫痫治疗的患者N75 - P100的振幅显著降低（p = 0.035）。
这些结果表明，IGE + PS组具有由未知且独特的分子机制驱动的不同光阵发性反应表型。与IGE - PS组或健康组相比，IGE + PS患者的预激活皮质兴奋性可能增加。模式反转视觉诱发电位习惯化可能反映了光敏性的病理生理机制，并且可能是IGE + PS患者的潜在生物标志物。
