Kurita-Tashima S, Tobimatsu S, Nakayama-Hiromatsu M, Kato M
Department of Clinical Neurophysiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Electroencephalogr Clin Neurophysiol. 1991 May-Jun;80(3):161-6. doi: 10.1016/0168-5597(91)90118-h.
Modifications of the components of pattern-reversal visual evoked potentials (PR-VEP) with changes in check size of the stimulating pattern were studied in 11 healthy subjects. We made use of 8 different check sizes ranging between 10 and 90 min of arc. Changes in the check size modified in different manners the latencies and amplitudes of N75, P100 and N145. Two-step statistical analyses using the polynomial regression analysis method revealed significant modifications of latencies of the 3 components, but non-significant modifications of the amplitudes, except for N75. The latency and amplitude of N75 showed a significant inverse linear relationship with the logarithm of the check size, while the P100 and N145 latencies showed significant curvilinear relationships, with minimal latencies at check sizes around 35 min. These findings suggest different physiological properties of N75 from those of P100 and N145, and hence, the necessity to establish normal values for each check size of stimulation, for application in clinical studies.
在11名健康受试者中研究了随着刺激图形方格大小的变化，图形翻转视觉诱发电位（PR-VEP）各成分的变化情况。我们采用了8种不同的方格大小，范围在10到90分视角之间。方格大小的变化以不同方式改变了N75、P100和N145的潜伏期和波幅。使用多项式回归分析方法进行的两步统计分析显示，除N75外，这3个成分的潜伏期有显著改变，而波幅无显著改变。N75的潜伏期和波幅与方格大小的对数呈显著负线性关系，而P100和N145的潜伏期呈显著曲线关系，在方格大小约为35分视角时潜伏期最短。这些发现提示N75与P100和N145具有不同的生理特性，因此有必要为每种刺激方格大小建立正常值，以便应用于临床研究。
