Nickels Matt, Mastana Sarabjit, Hunter David, Denniff Matthew, Codd Veryan, Akam Elizabeth
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire, LE11 3TU, United Kingdom.
Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom.
Heliyon. 2020 Jun 10;6(6):e04151. doi: 10.1016/j.heliyon.2020.e04151. eCollection 2020 Jun.
Telomere dynamics are an active biological process and positive lifestyle factors such as exercise are proposed to potentiate their length. The aim of this study was to investigate the effect of a low-resistance, high-repetition resistance training intervention on leukocyte telomere length (LTL) and associated health parameters. 23 sedentary middle-aged adults volunteered for this study (16 female/7 male; age = 51.5 ± 4.9 years) and performed two one-hour sessions of Les Mills BODYPUMP™ per week for 12 weeks. Outcome measures were taken at baseline, after the training intervention and at 12-month follow-up. LTL remained unchanged following the training intervention (pre 0.819 ± 0.121 vs post 0.812 ± 0.114, p = 0.420), despite a borderline significant increase in hTERT expression (p = 0.050). Circulating levels of tumour necrosis factor alpha were reduced after the intervention (p = 0.001). At 12-month follow-up, subjects who returned to a sedentary lifestyle (n = 10) displayed shorter telomeres compared to their pre (p = 0.036) values. In conclusion, no changes were observed in LTL following the 12-week training intervention, despite improvements in molecular parameters associated with telomere dynamics. It appears continued long-term exercise (>12 months) is necessary to preserve LTL in previously sedentary individuals.
端粒动态变化是一个活跃的生物学过程，诸如运动等积极的生活方式因素被认为可以延长端粒长度。本研究旨在探讨低阻力、高重复次数的抗阻训练干预对白细胞端粒长度（LTL）及相关健康参数的影响。23名久坐不动的中年成年人自愿参与本研究（16名女性/7名男性；年龄 = 51.5 ± 4.9岁），他们每周进行两次为时一小时的莱美杠铃操课程，共持续12周。在基线期、训练干预后以及12个月随访时进行结果测量。尽管hTERT表达有临界显著增加（p = 0.050），但训练干预后LTL仍保持不变（干预前0.819 ± 0.121 vs干预后0.812 ± 0.114，p = 0.420）。干预后肿瘤坏死因子α的循环水平降低（p = 0.001）。在12个月随访时，恢复久坐生活方式的受试者（n = 10）的端粒长度相较于干预前缩短（p = 0.036）。总之，尽管与端粒动态变化相关的分子参数有所改善，但12周训练干预后未观察到LTL有变化。对于既往久坐的个体而言，似乎需要持续长期运动（>12个月）来维持LTL。
