State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.
University of Science and Technology of China, Hefei 230026, P. R. China.
ACS Appl Mater Interfaces. 2020 Jul 8;12(27):30077-30084. doi: 10.1021/acsami.0c06144. Epub 2020 Jun 28.
Organelle-targeting techniques have been proved to be promising approaches for enhanced cancer treatment, especially phototherapy, because it can greatly improve the efficiency of photosensitizers. In this work, we designed and synthesized a mitochondria-targeting diketopyrrolopyrrole-based photosensitizer (DPP2+) for synergistic photodynamic/photothermal therapy upon irradiation. The obtained mitochondria-targeting nanoparticles (DPP2+ NPs) could produce thermal energy and singlet oxygen under 635 nm laser irradiation with ideal cytocompatibility. Importantly, DPP2+ NPs are more likely to enter the cells and target mitochondria. In in vitro and in vivo antitumor experiments, DPP2+ NPs showed highly effective antitumor effects, suggesting that mitochondria-targeting photosensitizers have potential for cancer treatment. The present work provides an alternative strategy to mitochondria-targeting molecular engineering and highlights the potential of organic nanomaterials in biomedical fields and cancer treatment.
细胞器靶向技术已被证明是增强癌症治疗的有前途的方法，特别是光疗，因为它可以大大提高光敏剂的效率。在这项工作中，我们设计并合成了一种基于二酮吡咯并吡咯的线粒体靶向光敏剂（DPP2+），用于光动力/光热协同治疗。所得的线粒体靶向纳米粒子（DPP2+ NPs）在 635nm 激光照射下可产生热能和单线态氧，具有理想的细胞相容性。重要的是，DPP2+ NPs 更有可能进入细胞并靶向线粒体。在体外和体内抗肿瘤实验中，DPP2+ NPs 表现出高效的抗肿瘤作用，表明线粒体靶向光敏剂在癌症治疗方面具有潜力。本工作为线粒体靶向分子工程提供了一种替代策略，并强调了有机纳米材料在生物医学领域和癌症治疗中的潜力。
