Centre for Bioinformatics Research, Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
Centre for Plant Biotechnology, Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
J Agric Food Chem. 2020 Jul 15;68(28):7281-7297. doi: 10.1021/acs.jafc.0c01916. Epub 2020 Jul 1.
Glucosinolates (GSLs) are plant secondary metabolites comprising sulfur and nitrogen mainly found in plants from the order of Brassicales, such as broccoli, cabbage, and . The activated forms of GSL play important roles in fighting against pathogens and have health benefits to humans. The increasing amount of data on generated from various omics technologies can be investigated more deeply in search of new genes or compounds involved in GSL biosynthesis and metabolism. This review describes a comprehensive inventory of GSLs identified from published literature and databases such as KNApSAcK, KEGG, and AraCyc. A total of 113 GSL genes encoding for 23 transcription components, 85 enzymes, and five protein transporters were experimentally characterized in the past two decades. Continuous efforts are still on going to identify all molecules related to the production of GSLs. A manually curated database known as SuCCombase (http://plant-scc.org) was developed to serve as a comprehensive GSL inventory. Realizing lack of information on the regulation of GSL biosynthesis and degradation mechanisms, this review also includes relevant information and their connections with crosstalk among various factors, such as light, sulfur metabolism, and nitrogen metabolism, not only in but also in other crucifers.
硫代葡萄糖苷（GSLs）是一种植物次生代谢物，主要包含硫和氮，主要存在于芸薹属植物中，如西兰花、卷心菜等。GSL 的活性形式在抵御病原体方面发挥着重要作用，对人类健康有益。随着越来越多的关于 GSL 生物合成和代谢的相关数据来自于各种组学技术，可以更深入地研究这些数据，以寻找新的基因或参与 GSL 生物合成和代谢的化合物。本文综述了从已发表文献和 KNApSAcK、KEGG、AraCyc 等数据库中鉴定出的 GSL 的综合清单。在过去的二十年中，有 113 个 GSL 基因被实验鉴定为 23 个转录成分、85 种酶和 5 种蛋白质转运体。目前仍在继续努力以鉴定与 GSL 产生相关的所有分子。开发了一个名为 SuCCombase（http://plant-scc.org）的人工整理数据库，作为一个全面的 GSL 清单。鉴于缺乏关于 GSL 生物合成和降解机制调控的信息，本文还包括了相关信息及其与各种因素之间相互作用的联系，如光、硫代谢和氮代谢，不仅在 中，而且在其他十字花科植物中也是如此。
