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双模态 PNA 的结构设计与合成，可同时与两条互补 DNA 结合形成融合双链体。

Structural Design and Synthesis of Bimodal PNA That Simultaneously Binds Two Complementary DNAs To Form Fused Double Duplexes.

机构信息

Department of Chemistry, Indian Institute of Science Education and Research (IISER) Pune, Dr Homi Bhabha Road, Pune 411008, India.

Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Karkambadi Road, Tirupati 517507, India.

出版信息

Org Lett. 2020 Jul 2;22(13):5255-5260. doi: 10.1021/acs.orglett.0c01950. Epub 2020 Jun 18.

DOI:10.1021/acs.orglett.0c01950
PMID:32551691
Abstract

Bimodal PNAs are new PNA constructs designed to bind two different cDNA sequences synchronously to form double duplexes. They are synthesized on solid phase using sequential coupling and click reaction to introduce a second base in each monomer at C via alkyltriazole linker. The ternary bimodal PNA:DNA complexes show stability higher than that of individual duplexes. Bimodal PNAs are appropriate to create higher-order fused nucleic acid assemblies.

摘要

双模态 PNAs 是新设计的 PNA 构建体，旨在同时结合两个不同的 cDNA 序列以形成双双链。它们在固相上通过顺序偶联和点击反应合成，通过烷基三唑连接子在每个单体的 C 上引入第二个碱基。三元双模态 PNA:DNA 复合物表现出比单个双链更高的稳定性。双模态 PNAs 适合于构建更高阶的融合核酸组装体。

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