Lee K, Nam J H
Acta Virol. 2020;64(2):251-260. doi: 10.4149/av_2020_208.
Middle East respiratory syndrome coronavirus (MERS-CoV) is an RNA virus that causes severe respiratory disease. Since it was identified in 2012, approximately 2500 MERS cases with high mortality have been confirmed in 27 countries. Although most cases have occurred in the Middle East, an outbreak in South Korea in 2015 showed that MERS could be a global threat via human-to-human transmission. There is no licensed vaccine against MERS. Thus, early detection is the best way to limit the spread of this fatal disease. In this review, we focus on transmission, the infection process, and scientific efforts in vaccine development and diagnostics for MERS-CoV. Keywords: Middle East respiratory syndrome coronavirus; epidemiology; virology; vaccine; diagnostics.
中东呼吸综合征冠状病毒（MERS-CoV）是一种可引发严重呼吸道疾病的RNA病毒。自2012年被发现以来，27个国家已确诊约2500例高死亡率的中东呼吸综合征病例。尽管大多数病例发生在中东地区，但2015年韩国的一次疫情爆发表明，中东呼吸综合征可通过人际传播成为全球威胁。目前尚无针对中东呼吸综合征的许可疫苗。因此，早期检测是限制这种致命疾病传播的最佳方法。在本综述中，我们重点关注中东呼吸综合征冠状病毒的传播、感染过程以及疫苗研发和诊断方面的科学努力。关键词：中东呼吸综合征冠状病毒；流行病学；病毒学；疫苗；诊断。
