Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
Department of Psychology, University of Colorado Denver, Denver, Colorado.
Am J Physiol Regul Integr Comp Physiol. 2020 Aug 1;319(2):R171-R183. doi: 10.1152/ajpregu.00259.2019. Epub 2020 Jun 17.
Exercise is often used as a strategy for weight loss maintenance. In preclinical models, we have shown that exercise may be beneficial because it counters the biological drive to regain weight. However, our studies have demonstrated sex differences in the response to exercise in this context. In the present study, we sought to better understand why females and males exhibit different compensatory food eating behaviors in response to regular exercise. Using a forced treadmill exercise paradigm, we measured weight gain, energy expenditure, food intake in real time, and the anorectic effects of leptin. The 4-wk exercise training resulted in reduced weight gain in males and sustained weight gain in females. In male rats, exercise decreased intake, whereas it increased food intake in females. Our results suggest that the anorectic effects of leptin were not responsible for these sex differences in appetite in response to exercise. If these results translate to the human condition, they may reveal important information for the use and application of regular exercise programs.
运动常被用作体重维持的策略。在临床前模型中，我们已经表明，运动可能是有益的，因为它可以对抗恢复体重的生物驱动力。然而，我们的研究表明，在这种情况下，运动对男女的反应存在性别差异。在本研究中，我们试图更好地理解为什么女性和男性在对常规运动的反应中表现出不同的补偿性食物摄入行为。使用强制跑步机运动范式，我们测量了体重增加、能量消耗、实时食物摄入以及瘦素的厌食作用。4 周的运动训练导致雄性体重增加减少，而雌性体重持续增加。在雄性大鼠中，运动减少了摄食量，而在雌性大鼠中则增加了食物摄入量。我们的结果表明，瘦素的厌食作用并不是导致运动对食欲产生性别差异的原因。如果这些结果适用于人类，它们可能为常规运动计划的使用和应用提供重要信息。
