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Update Alert: Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19? Living Practice Points From the American College of Physicians.最新警报：临床医生应单独使用氯喹或羟氯喹，还是与阿奇霉素联合使用来预防或治疗新型冠状病毒肺炎？美国医师协会的实践要点
Ann Intern Med. 2020 Jul 21;173(2):W48-W51. doi: 10.7326/M20-3862. Epub 2020 Jun 17.
2
Update Alert 2: Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19? Living Practice Points From the American College of Physicians.最新警报2：临床医生应单独使用氯喹或羟氯喹，还是与阿奇霉素联合使用来预防或治疗新型冠状病毒肺炎？美国医师协会的临床实践要点
Ann Intern Med. 2020 Sep 1;173(5):W88-W89. doi: 10.7326/L20-1007. Epub 2020 Jul 30.
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Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19? Living Practice Points From the American College of Physicians (Version 1).临床医生应单独使用氯喹或羟氯喹，还是与阿奇霉素联合使用来预防或治疗新型冠状病毒肺炎？美国医师协会的临床实践要点（第1版）
Ann Intern Med. 2020 Jul 21;173(2):137-142. doi: 10.7326/M20-1998. Epub 2020 May 13.
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Update Alert: Hydroxychloroquine or Chloroquine for the Treatment or Prophylaxis of COVID-19.最新警报：羟氯喹啉或氯喹啉用于治疗或预防2019冠状病毒病
Ann Intern Med. 2020 Aug 18;173(4):W78-W79. doi: 10.7326/L20-0945. Epub 2020 Jul 15.
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Update Alert 2: Hydroxychloroquine or Chloroquine for the Treatment or Prophylaxis of COVID-19.更新警报2：羟氯喹或氯喹用于治疗或预防新型冠状病毒肺炎
Ann Intern Med. 2020 Oct 6;173(7):W128-W129. doi: 10.7326/L20-1054. Epub 2020 Aug 27.
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Effect of Chloroquine, Hydroxychloroquine, and Azithromycin on the Corrected QT Interval in Patients With SARS-CoV-2 Infection.氯喹、羟氯喹和阿奇霉素对 SARS-CoV-2 感染患者校正 QT 间期的影响。
Circ Arrhythm Electrophysiol. 2020 Jun;13(6):e008662. doi: 10.1161/CIRCEP.120.008662. Epub 2020 Apr 29.
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The continued dilemma about the usage of hydroxychloroquine: Respite is in randomized control trials.羟氯喹使用方面持续存在的困境：随机对照试验带来了缓解。
Int J Infect Dis. 2020 Oct;99:310-311. doi: 10.1016/j.ijid.2020.07.054. Epub 2020 Jul 29.
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Response to the editorial "COVID-19 in patients with cardiovascular diseases": Covid-19 treatment with hydroxychloroquine or chloroquine and azithromycin: A potential risk of Torsades de Pointes.对社论《心血管疾病患者的COVID-19》的回应：使用羟氯喹或氯喹及阿奇霉素治疗COVID-19：尖端扭转型室速的潜在风险。
Arch Cardiovasc Dis. 2020 May;113(5):367-368. doi: 10.1016/j.acvd.2020.04.001. Epub 2020 Apr 15.
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Benefit v. risk when using chloroquine in patients with severe COVID-19 disease.在重症新型冠状病毒肺炎患者中使用氯喹时的获益与风险
S Afr Med J. 2020 Apr 2;110(5):12903. doi: 10.7196/SAMJ.2020.v110i5.14761.
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Hydroxychloroquine-azithromycin for COVID-19 - Warranted or dangerous?用于治疗COVID-19的羟氯喹啉-阿奇霉素——合理还是危险？
Travel Med Infect Dis. 2020 May-Jun;35:101764. doi: 10.1016/j.tmaid.2020.101764. Epub 2020 May 30.

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Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study.盐酸氨溴索对医务人员预防新型冠状病毒肺炎的随机开放标签研究
Interdiscip Perspect Infect Dis. 2022 Jan 29;2022:4693121. doi: 10.1155/2022/4693121. eCollection 2022.
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COVID-19, hydroxychloroquine and the importance of disease progression.新型冠状病毒肺炎、羟氯喹与疾病进展的重要性
Toxicol Res (Camb). 2021 Mar 9;10(2):299-311. doi: 10.1093/toxres/tfab015. eCollection 2021 Mar.
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Severe COVID-19: A distinct entity.重症新型冠状病毒肺炎：一种独特的疾病实体。
J Family Med Prim Care. 2021 Jan;10(1):84-92. doi: 10.4103/jfmpc.jfmpc_1600_20. Epub 2021 Jan 30.
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Exploring insights of hydroxychloroquine, a controversial drug in Covid-19: An update.探讨羟氯喹在新冠病毒中的作用：一个有争议的药物的更新。
Food Chem Toxicol. 2021 May;151:112106. doi: 10.1016/j.fct.2021.112106. Epub 2021 Mar 15.
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Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2).计算药物再利用策略预测了潜在能够抑制 SARS-CoV-2 刺突蛋白与其靶标（人 ACE2）相互作用的基于肽的药物。
PLoS One. 2021 Jan 8;16(1):e0245258. doi: 10.1371/journal.pone.0245258. eCollection 2021.
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Comparing and Contrasting MERS, SARS-CoV, and SARS-CoV-2: Prevention, Transmission, Management, and Vaccine Development.中东呼吸综合征、严重急性呼吸综合征冠状病毒和严重急性呼吸综合征冠状病毒2的比较与对比：预防、传播、管理及疫苗研发
Pathogens. 2020 Nov 26;9(12):985. doi: 10.3390/pathogens9120985.
7
Update Alert 2: Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19? Living Practice Points From the American College of Physicians.最新警报2：临床医生应单独使用氯喹或羟氯喹，还是与阿奇霉素联合使用来预防或治疗新型冠状病毒肺炎？美国医师协会的临床实践要点
Ann Intern Med. 2020 Sep 1;173(5):W88-W89. doi: 10.7326/L20-1007. Epub 2020 Jul 30.

本文引用的文献

1
Preliminary evidence from a multicenter prospective observational study of the safety and efficacy of chloroquine for the treatment of COVID-19.一项关于氯喹治疗COVID-19安全性和有效性的多中心前瞻性观察性研究的初步证据。
Natl Sci Rev. 2020 May 28;7(9):1428-1436. doi: 10.1093/nsr/nwaa113. eCollection 2020 Sep.
2
Hydroxychloroquine is associated with slower viral clearance in clinical COVID-19 patients with mild to moderate disease.在患有轻至中度疾病的临床新冠肺炎患者中，羟氯喹与病毒清除较慢有关。
Medicine (Baltimore). 2020 Dec 24;99(52):e23720. doi: 10.1097/MD.0000000000023720.
3
Outcomes of Hydroxychloroquine Usage in United States Veterans Hospitalized with COVID-19.羟氯喹在美国 COVID-19 住院患者中的使用效果。
Med. 2020 Dec 18;1(1):114-127.e3. doi: 10.1016/j.medj.2020.06.001. Epub 2020 Jun 5.
4
Update Alert 2: Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19? Living Practice Points From the American College of Physicians.最新警报2：临床医生应单独使用氯喹或羟氯喹，还是与阿奇霉素联合使用来预防或治疗新型冠状病毒肺炎？美国医师协会的临床实践要点
Ann Intern Med. 2020 Sep 1;173(5):W88-W89. doi: 10.7326/L20-1007. Epub 2020 Jul 30.
5
Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19: A Living Systematic Review.羟氯喹或氯喹治疗或预防 COVID-19：一项实时系统评价。
Ann Intern Med. 2020 Aug 18;173(4):287-296. doi: 10.7326/M20-2496. Epub 2020 May 27.
6
[A pilot study of hydroxychloroquine in treatment of patients with moderate COVID-19].羟氯喹治疗中度新型冠状病毒肺炎患者的一项试点研究
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020 May 25;49(2):215-219. doi: 10.3785/j.issn.1008-9292.2020.03.03.
7
Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19.羟氯喹治疗 COVID-19 住院患者的观察性研究。
N Engl J Med. 2020 Jun 18;382(25):2411-2418. doi: 10.1056/NEJMoa2012410. Epub 2020 May 7.
8
Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial.羟氯喹和阿奇霉素治疗 COVID-19：一项开放标签非随机临床试验的结果。
Int J Antimicrob Agents. 2020 Jul;56(1):105949. doi: 10.1016/j.ijantimicag.2020.105949. Epub 2020 Mar 20.
9
Cluster randomised controlled trial to examine medical mask use as source control for people with respiratory illness.群组随机对照试验，以检验使用医用口罩作为呼吸道疾病患者的源头控制措施。
BMJ Open. 2016 Dec 30;6(12):e012330. doi: 10.1136/bmjopen-2016-012330.
10
Face mask use and control of respiratory virus transmission in households.家庭中使用口罩与呼吸道病毒传播的控制
Emerg Infect Dis. 2009 Feb;15(2):233-41. doi: 10.3201/eid1502.081167.

Update Alert: Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19? Living Practice Points From the American College of Physicians.

作者信息

Qaseem Amir, Yost Jennifer, Etxeandia-Ikobaltzeta Itziar, Miller Matthew C, Abraham George M, Obley Adam J, Forciea Mary Ann, Jokela Janet A, Humphrey Linda L

机构信息

American College of Physicians, Philadelphia, Pennsylvania (A.Q.).

Villanova University, Villanova, Pennsylvania (J.Y.).

出版信息

Ann Intern Med. 2020 Jul 21;173(2):W48-W51. doi: 10.7326/M20-3862. Epub 2020 Jun 17.

DOI:10.7326/M20-3862
PMID:32551892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7322813/
Abstract
摘要