Vujosevic Stela, Toma Caterina, Muraca Andrea, Alkabes Micol, Villani Edoardo, Nucci Paolo, De Cilla Stefano
University Eye Clinic San Giuseppe Hospital, IRCCS MultiMedica, Milan, Italy.
Eye Unit, University Hospital Maggiore della Carita', Novara, Italy.
Eur J Ophthalmol. 2021 Sep;31(5):NP106-NP110. doi: 10.1177/1120672120934745. Epub 2020 Jun 17.
To describe a case of unilateral multiple bullous neurosensory retina detachments (NRDs) secondary to non-Hodgkin's aggressive large B-cell lymphoma treated with chemotherapy and high doses of systemic steroids.
A case report based on patient observation, clinical records, and retinal imaging during 2 years of follow-up.
A 26-year-old Hispanic man presented at our clinic with sudden unilateral visual loss and multiple NRDs in the left eye with increased choroidal thickness, 1 week after oral steroid treatment due to low back pain and fever. In the following days, a non-Hodgkin's aggressive large B-cell lymphoma was diagnosed. The patient underwent three cycles of chemotherapy (CHT) with protocol R-CHOP21 (including oral prednisone) with complete resolution of NRD. During 2 years of follow-up, no recurrence of NRD occurred, despite the need to continue CHT with oral steroids for a year due to lymphoma relapse.
Neurosensory retina detachments may be an initial manifestation of large B-cell lymphoma as a consequence of a pro-inflammatory state involving the chorioretinal structures, thus adding steroid treatment could be useful for its resolution.
