School of Agriculture, Tokai University, Kumamoto, Japan.
Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
Nat Prod Res. 2022 Jan;36(1):326-333. doi: 10.1080/14786419.2020.1781117. Epub 2020 Jun 19.
A new cholestane-type steroidal glycoside, solamyriaside A (), was isolated from the fruits of Dunal (Solanaceae), along with two known steroidal glycosides, namely, solaviaside A () and aculeatiside A (), and three known steroidal alkaloid glycosides, namely, solamargine (), khasianine () and solasonine (), which were isolated for the first time from this plant. Based on spectroscopic data as well as chemical evidence, was determined to be 3--α-L-rhamnopyranosyl-(1→2)--[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranosyl-22,25-cholest-5-ene-3β,16α,22,26-tetraol 26--β-D-glucopyranoside. The cytotoxic activity of - against HL-60 human promyelocytic leukaemia cells was examined. Compounds - showed cytotoxic activity. Among them, exhibited the strongest activity with an IC value of 4.64 ± 0.17 μM, similar to the activity of cisplatin, a positive control.
一种新的胆甾烷型甾体糖苷，索拉米亚苷 A（），从 Dunal（茄科）的果实中分离得到，此外还有两种已知的甾体糖苷，即索拉维亚苷 A（）和刺茄苷 A（），以及三种已知的甾体生物碱糖苷，即索拉马林（）、khasianine（）和茄碱（），它们均首次从该植物中分离得到。基于光谱数据和化学证据，确定为 3--α-L-鼠李吡喃糖基-(1→2)-[α-L-鼠李吡喃糖基-(1→4)]-β-D-吡喃葡萄糖基-22,25-胆甾-5-烯-3β,16α,22,26-四醇 26--β-D-吡喃葡萄糖苷。对 - 对 HL-60 人早幼粒细胞白血病细胞的细胞毒性活性进行了检测。化合物 - 表现出细胞毒性活性。其中，表现出最强的活性，IC 值为 4.64 ± 0.17 μM，与阳性对照顺铂的活性相当。
