Cytotoxic activity of steroidal glycosides from the aerial parts of collected in Thua Thien Hue, Vietnam.

A phytochemical investigation of led to the isolation of eleven steroidal glycosides, including neochlorogenin 6---D-quinovopyranoside (), (22 ,23,25)-3-6,23-trihydroxy-5-spirostane 6---D-xylopyranosyl-(1→3)--D-quinovopyranoside (), neochlorogenin 6---L-rhamnopyranosyl-(1→3)--D-quinovopyranoside (), solagenin 6---L-rhamnopyranosyl-(1→3)--D-quinovopyranoside (), paniculonin A (), paniculonin B (), 6α--[-D-xylopyranosyl-(1→3)-D-quinovopyranosyl]-(25)-5α-spirostan-3-ol (), torvoside J (), torvoside K (), torvoside L () and solagenin 6---D-quinovopyranoside (). Their chemical structures were elucidated by 1D-NMR and 2D-NMR data as well as comparison with the data reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against SK-LU-1, HepG2, MCF-7 and T24 cancer cell lines. Among them, compounds , , and exhibited cytotoxicity against all four tested cell lines with IC values ranging from 7.89 ± 0.87 to 46.76 ± 3.88 µM.