Mientrung Institute for Scientific Research,Vietnam Academy of Science and Technology (VAST), Hue City, Vietnam.
Graduate University of Science and Technology (VAST), Hanoi, Vietnam.
Nat Prod Res. 2021 Dec;35(23):5502-5507. doi: 10.1080/14786419.2020.1788022. Epub 2020 Jul 1.
A phytochemical investigation of led to the isolation of eleven steroidal glycosides, including neochlorogenin 6---D-quinovopyranoside (), (22 ,23,25)-3-6,23-trihydroxy-5-spirostane 6---D-xylopyranosyl-(1→3)--D-quinovopyranoside (), neochlorogenin 6---L-rhamnopyranosyl-(1→3)--D-quinovopyranoside (), solagenin 6---L-rhamnopyranosyl-(1→3)--D-quinovopyranoside (), paniculonin A (), paniculonin B (), 6α--[-D-xylopyranosyl-(1→3)-D-quinovopyranosyl]-(25)-5α-spirostan-3-ol (), torvoside J (), torvoside K (), torvoside L () and solagenin 6---D-quinovopyranoside (). Their chemical structures were elucidated by 1D-NMR and 2D-NMR data as well as comparison with the data reported in the literature. Moreover, all isolated compounds were evaluated for their cytotoxic activities against SK-LU-1, HepG2, MCF-7 and T24 cancer cell lines. Among them, compounds , , and exhibited cytotoxicity against all four tested cell lines with IC values ranging from 7.89 ± 0.87 to 46.76 ± 3.88 µM.
从 led 中进行的植物化学研究分离得到了 11 种甾体糖苷，包括新克罗苷元 6---D-奎尼糖苷（）、（22,23,25）-3-6,23-二羟基-5-螺甾烷 6---D-木糖基-(1→3)--D-奎尼糖苷（）、新克罗苷元 6---L-鼠李糖苷-(1→3)--D-奎尼糖苷（）、薯蓣皂苷元 6---L-鼠李糖苷-(1→3)--D-奎尼糖苷（）、 paniculonin A（）、paniculonin B（）、6α--[-D-木糖基-(1→3)-D-奎尼糖苷基]-(25)-5α-螺甾烷-3-醇（）、torvoside J（）、torvoside K（）、torvoside L（）和薯蓣皂苷元 6---D-奎尼糖苷（）。它们的化学结构通过 1D-NMR 和 2D-NMR 数据以及与文献报道的数据进行了阐明。此外，还评估了所有分离得到的化合物对 SK-LU-1、HepG2、MCF-7 和 T24 癌细胞系的细胞毒性活性。其中，化合物、、和对所有四种测试的细胞系均具有细胞毒性活性，IC 值范围为 7.89±0.87 至 46.76±3.88µM。
