Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, The Netherlands.
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy and Neurosciences, Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, The Netherlands.
Neurodegener Dis Manag. 2020 Jun;10(3):159-168. doi: 10.2217/nmt-2019-0028. Epub 2020 Jun 17.
We studied the longitudinal associations between freezing of gait (FoG), fear of falling (FoF) and anxiety, and how these associations are influenced by confounding factors. We analyzed longitudinal motor and nonmotor measurements from 153 Parkinson's disease patients. Possible confounding factors were divided into three subgroups: demographics, disease characteristics, medication use and adverse effects of medication. All crude associations between FoG, FoF and anxiety were significant and remained so after adjusting for confounders. When analyzing FoF and anxiety together as independent variables, the association between FoG and FoF remained, and the association between FoG and anxiety diminished. We confirm the complex interactions between motor and nonmotor symptoms in Parkinson's disease, and plead for a multidisciplinary approach.
我们研究了冻结步态（FoG）、跌倒恐惧（FoF）和焦虑之间的纵向关联，以及这些关联如何受到混杂因素的影响。我们分析了 153 名帕金森病患者的纵向运动和非运动测量值。可能的混杂因素分为三组：人口统计学、疾病特征、药物使用和药物不良反应。FoG、FoF 和焦虑之间的所有原始关联均具有统计学意义，且在调整混杂因素后仍然如此。当将 FoF 和焦虑一起作为独立变量进行分析时，FoG 和 FoF 之间的关联仍然存在，而 FoG 和焦虑之间的关联减弱。我们证实了帕金森病中运动和非运动症状之间的复杂相互作用，并呼吁采取多学科方法。
