Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine, 59 Daesagwan-ro, Yongsan-gu, Seoul, 04401, Republic of Korea.
Department of Biostatistics and Data Innovation, Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine, Seoul, Republic of Korea.
Sci Rep. 2021 Mar 4;11(1):5171. doi: 10.1038/s41598-021-84720-w.
The association of non-motor symptoms (NMSs) with fall-related factors in patients with Parkinson's disease (PD) remains to be further elucidated in the early stages of the disease. Eighty-six patients with less than 5 years of the onset of PD were retrospectively enrolled in the study. We assessed potential fall-related risk factors including (1) a history of falls during the past year (faller versus non-faller), (2) the fear of falling (FoF), and (3) the freezing of gait (FoG). Different types of NMSs were measured using the Montreal Cognitive Assessment (MoCA), the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Parkinson's disease Fatigue Scale (PFS), and the Scales for Outcomes in Parkinson's disease-Autonomic dysfunction (SCOPA-AUT). The faller group (37.2%) showed higher scores for BDI, BAI, PFS, and SCOPA-AUT, compared to the non-faller group. From logistic regression analyses, the prior history of falls was related to the gastrointestinal domain of SCOPA-AUT, FoF was associated with BAI, and gastrointestinal and urinary domains of SCOPA-AUT, and FoG was linked to BAI and gastrointestinal domain of SCOPA-AUT. In conclusion, we found that fall-related risk factors in patients with early PD were highly connected with gastrointestinal dysautonomia.
帕金森病（PD）患者的非运动症状（NMSs）与与跌倒相关的因素之间的关联在疾病的早期阶段仍需进一步阐明。本研究回顾性纳入了 86 例发病不足 5 年的 PD 患者。我们评估了可能与跌倒相关的危险因素，包括（1）过去一年的跌倒史（跌倒者与非跌倒者），（2）对跌倒的恐惧（FoF），和（3）冻结步态（FoG）。使用蒙特利尔认知评估（MoCA）、贝克抑郁量表（BDI）、贝克焦虑量表（BAI）、帕金森病疲劳量表（PFS）和帕金森病自主神经功能障碍量表（SCOPA-AUT）来测量不同类型的 NMSs。与非跌倒者相比，跌倒者组（37.2%）的 BDI、BAI、PFS 和 SCOPA-AUT 评分更高。通过逻辑回归分析，既往跌倒史与 SCOPA-AUT 的胃肠道领域相关，FoF 与 BAI 以及 SCOPA-AUT 的胃肠道和泌尿系统领域相关，而 FoG 与 BAI 和 SCOPA-AUT 的胃肠道领域相关。总之，我们发现早期 PD 患者的跌倒相关危险因素与胃肠道自主神经功能障碍高度相关。
