[中药单体逆转慢性髓性白血病多药耐药的研究进展——综述]

[Research Advance on Reversing Multidrug Resistance of Chronic Myeloid Leukemia by Chinese Herbal Monomer--Review].

作者信息

Sun Ying, Liu Wen-Jun

机构信息

Department of Pediatrics, Children's Blood and Tumor Research Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, Chinna.

Department of Pediatrics, Children's Blood and Tumor Research Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, Chinna,E-mail:

出版信息

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020 Jun;28(3):1064-1068. doi: 10.19746/j.cnki.issn.1009-2137.2020.03.058.

DOI:10.19746/j.cnki.issn.1009-2137.2020.03.058

PMID:32552983

Abstract

Abstract　　Chronic myeloid leukemia (CML) is a malignant myeloproliferative tumor which is originating from hematopoietic stem cells. Chemotherapy is the preferred made of treatment for the disease. However, in recent years, more and more patients have multidrug resistance (MDR) during treatment, which is the main cause of failure treatment, therefore, the search for effective reversal agents has important clinical significance. Traditional Chinese medicine derived reversal agents have the characteristics of multiple targets, low toxicity and high efficiency, which can reverse the drug resistance through different mechanisms, and the research potential is unlimited. In recent years, it has been widely concerned by scholars at home and abroad, especially the research on physcion, emodin, curcumin, matrine, gambogic acid, oridonin, ligustrazine, solanine and other monomers, which has made great advance. In this reviwe, the recent research advance on the reversal of MDR in chronic myeloid leukemia by Chinese medicine monomer is summarized briefly.

摘要

摘要　　慢性髓性白血病（CML）是一种起源于造血干细胞的恶性骨髓增殖性肿瘤。化疗是该疾病的首选治疗方式。然而，近年来，越来越多的患者在治疗过程中出现多药耐药（MDR），这是治疗失败的主要原因，因此，寻找有效的逆转剂具有重要的临床意义。中药来源的逆转剂具有多靶点、低毒高效的特点，可通过不同机制逆转耐药，研究潜力巨大。近年来，受到国内外学者的广泛关注，尤其是对大黄素甲醚、大黄素、姜黄素、苦参碱、藤黄酸、冬凌草甲素、川芎嗪、龙葵碱等单体的研究取得了很大进展。本文简要综述了中药单体逆转慢性髓性白血病多药耐药的研究进展。