Cancer Prevention and Treatment Institute of Chengdu, Center for Medicine Research and Translation, Chengdu Fifth People's Hospital/The Second Clinical Medical College, The Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 611137, P. R. China.
Clinical Trial Unit, Chengdu Fifth People's Hospital/The Second Clinical Medical College, The Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 611137, P. R. China.
Am J Chin Med. 2023;51(3):575-594. doi: 10.1142/S0192415X23500283. Epub 2023 Feb 23.
Breast cancer is a malignant disease with an increasing incidence. Chemotherapy is still an important means for breast cancer treatment, but multidrug resistance (MDR) greatly limits its clinical application. Therefore, the high-efficiency MDR reversal agents are urgently needed. Traditional Chinese medicine (TCM) monomers have unique advantages in reversing chemotherapeutic MDR because of its low toxicity, high efficiency, and ability to impact multiple targets. This review firstly summarizes the major mechanisms of MDR in breast cancer, including the reduced accumulation of intracellular chemotherapeutic drugs, the promoted inactivation of intracellular chemotherapeutic drugs, and the enhanced damage repair ability of DNA, etc., and secondly highlights the research progress of 15 kinds of TCM monomers, including curcumin, resveratrol, emodin, apigenin, tetrandrine, gambogic acid, matrine, paeonol, schisandrin B, [Formula: see text]-elemene, astragaloside IV, berberine, puerarin, tanshinone IIA, and quercetin, in reversing MDR of breast cancer. This review also provides the suggestion for the future research of MDR reversal agents in breast cancer.
乳腺癌是一种发病率不断增加的恶性疾病。化疗仍然是治疗乳腺癌的重要手段，但多药耐药（MDR）极大地限制了其临床应用。因此，急需高效的 MDR 逆转剂。由于毒性低、效率高、能够影响多个靶点等特点，中药单体在逆转化疗 MDR 方面具有独特的优势。本文首先总结了乳腺癌 MDR 的主要机制，包括细胞内化疗药物蓄积减少、细胞内化疗药物失活促进、DNA 损伤修复能力增强等，其次重点介绍了 15 种中药单体，包括姜黄素、白藜芦醇、大黄素、芹菜素、汉防己甲素、藤黄酸、苦参碱、五味子 B、[Formula: see text]-榄香烯、黄芪甲苷、小檗碱、葛根素、丹参酮 IIA 和槲皮素，在逆转乳腺癌 MDR 方面的研究进展。本文还为乳腺癌 MDR 逆转剂的未来研究提供了建议。
