J. David Gladstone Institutes, United States; Department of Medicine, University of California, San Francisco, United States.
J. David Gladstone Institutes, United States; Department of Medicine, University of California, San Francisco, United States.
Semin Cell Dev Biol. 2021 Mar;111:101-107. doi: 10.1016/j.semcdb.2020.05.018. Epub 2020 Jun 15.
The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of viral pathogens. In this review we highlight the reciprocal interactions between the host NMD pathway and viral pathogens, which have shaped both the host antiviral defense and viral pathogenesis.
无意义介导的 mRNA 降解（NMD）途径是真核细胞中保守的 RNA 质量控制途径。虽然历史上认为它主要识别具有过早终止密码子的转录本，但现在已知 NMD 途径发挥着多种作用，从稳态事件到控制病毒病原体。在这篇综述中，我们强调了宿主 NMD 途径与病毒病原体之间的相互作用，这些相互作用塑造了宿主抗病毒防御和病毒发病机制。
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