PARP-1 在线粒体动态平衡中的作用。
Role of PARP-1 in mitochondrial homeostasis.
机构信息
Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India.
Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India.
出版信息
Biochim Biophys Acta Gen Subj. 2020 Oct;1864(10):129669. doi: 10.1016/j.bbagen.2020.129669. Epub 2020 Jun 14.
BACKGROUND
Nuclear poly(ADP-ribose) polymerase-1 (PARP-1) is a well characterised protein that accounts for the majority of PARylation reactions using NAD as a substrate, regulating diverse cellular functions. In addition to its nuclear functions, several recent studies have identified localization of PARP-1 in mitochondria and emphasized its possible role in maintaining mitochondrial homeostasis. Various reports suggest that nuclear PARP-1 has been implicated in diverse mitochondria-specific communication processes.
SCOPE OF REVIEW
The present review emphasizes on the potential role of PARP-1 in mitochondrial processes such as bioenergetics, mtDNA maintenance, cell death and mitophagy.
MAJOR CONCLUSIONS
The origin of mitochondrial PARP-1 is still an enigma; however researchers are trying to establish the cross-talk between nuclear and mitochondrial PARP-1 and how these PARP-1 pools modulate mitochondrial activity.
GENERAL SIGNIFICANCE
A better understanding of the possible role of PARP-1 in mitochondrial homeostasis helps us to explore the potential therapeutic targets to protect mitochondrial dysfunctions.
背景
核多聚（ADP-核糖）聚合酶-1（PARP-1）是一种经过充分研究的蛋白质，它利用 NAD 作为底物，负责大多数 PAR 化反应，调节多种细胞功能。除了其核功能外，最近的几项研究还确定了 PARP-1 在线粒体中的定位，并强调了其在维持线粒体动态平衡中的可能作用。各种报告表明，核 PARP-1 参与了多种特定于线粒体的通讯过程。
综述范围
本综述强调了 PARP-1 在生物能量学、mtDNA 维持、细胞死亡和线粒体自噬等线粒体过程中的潜在作用。
主要结论
线粒体 PARP-1 的起源仍然是一个谜；然而，研究人员正在努力建立核 PARP-1 和线粒体 PARP-1 之间的交流，并探讨这些 PARP-1 池如何调节线粒体活性。
一般意义
更好地理解 PARP-1 在线粒体动态平衡中的可能作用有助于我们探索保护线粒体功能障碍的潜在治疗靶点。
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