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接种疫苗时间与 SARS-CoV-2 暴露和疾病严重程度风险。

Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity.

机构信息

Department of Preventive Medicine, Public Health & Microbiology. Medical School. Universidad Autónoma de Madrid, Madrid, Spain; IdiPAZ & CIBER Epidemiology & Public Health (CIBERESP) & IMDEA-Food Institute, CEI UAM-CSIC, Madrid, Spain.

Oncology Department, Clínica Universitaria de Navarra, Madrid, Spain.

出版信息

Int J Infect Dis. 2020 Aug;97:290-292. doi: 10.1016/j.ijid.2020.06.035. Epub 2020 Jun 14.

DOI:10.1016/j.ijid.2020.06.035
PMID:32553720
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7293836/
Abstract

A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19.

摘要

SARS-CoV-2 感染的感染剂量与疾病严重程度之间的关系尚未得到证实。在这里，我们报告了在马德里可能接触到不同接种剂量的 3 个人群。总体而言，每组人群均发展出不同的 COVID-19 临床形式。我们的数据支持在 SARS-CoV-2 暴露时更大的病毒接种剂量可能会导致更高的 COVID-19 重症风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e6/7293836/9e510fc93f91/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e6/7293836/210cf85a402d/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e6/7293836/d5a20202d742/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e6/7293836/9e510fc93f91/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e6/7293836/210cf85a402d/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e6/7293836/d5a20202d742/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e6/7293836/9e510fc93f91/gr3_lrg.jpg

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