Monell Chemical Senses Center, Philadelphia, PA.
Monell Chemical Senses Center, Philadelphia, PA.
J Pediatr. 2020 Oct;225:174-181.e2. doi: 10.1016/j.jpeds.2020.06.019. Epub 2020 Jun 15.
To determine whether early diet and weight gain velocity have independent or interactive effects on deciduous teeth emergence and overweight status during the first year.
Monthly measures of anthropometry and teeth eruption were collected during a 1-year trial (0.5-12.5 months) on formula-fed infants in which the type of randomized infant formula (cow milk or extensively hydrolyzed protein) diet significantly affected early (0.5-4.5 months) weight gain velocity. Generalized linear mixed models determined whether early diet and weight gain velocity had independent or interactive effects on timing and pattern of teeth eruption. Data from a trial on breastfed infants were used to explore effects of breast milk vs infant formula diets on teeth eruption and overweight status at 10.5 months.
Independent of infant formula diet, velocities of weight gain had direct effects on the age of first deciduous tooth (P < .04) and number of erupted teeth over time (P < .002). Greater velocity of weight gain from 0.5 to 4.5 months caused earlier and more frequent eruption of deciduous teeth from 4.5 to 12.5 months. Exploratory follow-up analyses on the breastfed and formula-fed diet groups found early weight gain velocity (P = .001), but not diet or its interaction, had significant effects. Infants in the upper quartile for weight gain velocity had more primary teeth (P = .002), and a greater proportion of them were overweight (P < .001) at 10.5 months.
Faster weight gain accretion forecasted accelerated primary teeth eruption and increased percentage of children who were overweight-risk factors for dental caries and obesity.
ClinicalTrials.govNCT01700205 [2012-2015] and NCT01667549 [2012-2015].
确定早期饮食和体重增长速度是否对婴儿第一年的乳牙萌出和超重状况有独立或交互作用。
在一项为期 1 年的试验（0.5-12.5 个月）中，对配方奶喂养的婴儿进行每月的人体测量和牙齿萌出测量，该试验中随机的婴儿配方（牛奶或深度水解蛋白）饮食显著影响早期（0.5-4.5 个月）的体重增长速度。广义线性混合模型确定了早期饮食和体重增长速度对牙齿萌出的时间和模式是否有独立或交互作用。母乳喂养婴儿试验的数据用于探索母乳与婴儿配方奶粉饮食对 10.5 个月时牙齿萌出和超重状况的影响。
与婴儿配方奶粉饮食无关，体重增长速度对第一颗乳牙的萌出年龄（P<.04）和随时间萌出的牙齿数量（P<.002）有直接影响。0.5-4.5 个月时体重增长速度越快，4.5-12.5 个月时乳牙萌出越早、越频繁。对母乳喂养和配方奶喂养饮食组的探索性随访分析发现，早期体重增长速度（P=.001），而不是饮食或其相互作用，有显著影响。体重增长速度较高的婴儿中，更多的人有更多的乳牙（P=.002），并且在 10.5 个月时，更多的人超重（P<.001），这些都是龋齿和肥胖的危险因素。
体重增长速度越快，预测乳牙萌出速度越快，超重风险的儿童比例越高。
ClinicalTrials.govNCT01700205[2012-2015]和 NCT01667549[2012-2015]。
