Exercise and Health Laboratory, Interdisciplinary Center for the Study of Human Performance, Faculdade de Motricidade Humana, Universidade de Lisboa, Cruz-Quebrada - Portugal, Portugal.
Exercise and Health Laboratory, Interdisciplinary Center for the Study of Human Performance, Faculdade de Motricidade Humana, Universidade de Lisboa, Cruz-Quebrada - Portugal, Portugal.
J Pediatr. 2020 Oct;225:166-173.e1. doi: 10.1016/j.jpeds.2020.06.018. Epub 2020 Jun 14.
To examine the associations of changes in physical activity and sedentary patterns with changes in cardiometabolic outcomes from childhood to adolescence.
Youth from the International Children's Accelerometry Database (n = 1088; 55% girls), aged 8-13 years and followed for ∼4 years, were used in this analysis. Hip-mounted accelerometers were used and all physical activity intensities were expressed as the % of total wear-time. Sedentary time was separated into time spent in bouts <10 minutes and ≥10 minutes. A composite z score for cardiometabolic risk (CMR score) was computed by summing the standardized values for systolic and diastolic blood pressure, triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and the inverse high-density lipoprotein cholesterol. Multivariate analyses were performed using adjusted linear regression models.
Increase in sedentary time was unfavorably associated with changes in CMR score (β = 0.021; CI 0.004-0.037), TG (β = 0.003; CI 0.001-0.005), and diastolic blood pressure (β = 0.068; CI 0.009-0.128). Decrease in moderate-to-vigorous physical activity was unfavorably associated with changes in LDL-c (β = -0.009; CI -0.017 to -0.001) and TG (β = -0.007; CI -0.013 to -0.001). Increase in ≥10 minutes sedentary time was unfavorably associated with changes in CMR score (β = 0.017; CI 0.004-0.030), LDL-c (β = 0.003; CI 0.000-0.005), and TG (β = 0.003; CI 0.000-0.004). Decrease in light-intensity physical activity was unfavorably associated with changes in CMR score (β = -0.020; CI = -0.040 to 0.000).
More physical activity and less prolonged sedentary time are beneficial for cardiometabolic health in youth transitioning to adolescence.
研究儿童期至青春期身体活动和久坐行为模式的变化与心脏代谢结局变化之间的关系。
本分析使用了国际儿童加速计数据库（n=1088；55%为女孩）中的青少年数据，年龄为 8-13 岁，随访时间约为 4 年。使用臀部佩戴的加速度计，所有身体活动强度均表示为总佩戴时间的%。久坐时间分为持续时间<10 分钟和≥10 分钟的时间。通过将收缩压和舒张压、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-c）和反向高密度脂蛋白胆固醇的标准化值相加，计算出心脏代谢风险综合评分（CMR 评分）。采用调整后的线性回归模型进行多变量分析。
久坐时间增加与 CMR 评分（β=0.021；CI 0.004-0.037）、TG（β=0.003；CI 0.001-0.005）和舒张压（β=0.068；CI 0.009-0.128）的变化呈负相关。中高强度体力活动减少与 LDL-c（β=-0.009；CI -0.017 至 -0.001）和 TG（β=-0.007；CI -0.013 至 -0.001）的变化呈负相关。≥10 分钟久坐时间增加与 CMR 评分（β=0.017；CI 0.004-0.030）、LDL-c（β=0.003；CI 0.000-0.005）和 TG（β=0.003；CI 0.000-0.004）的变化呈负相关。轻强度体力活动减少与 CMR 评分（β=-0.020；CI=-0.040 至 0.000）的变化呈负相关。
儿童期向青春期过渡期间，更多的身体活动和更少的长时间久坐对心脏代谢健康有益。
