Center for Tropical Medicine, Federal University of Pará, Belém, PA, Brazil; Center for Biological and Health Sciences, State University of Pará, Belém, PA, Brazil.
Center for Biological and Health Sciences, State University of Pará, Belém, PA, Brazil.
Life Sci. 2020 Sep 1;256:117979. doi: 10.1016/j.lfs.2020.117979. Epub 2020 Jun 15.
This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on language and publication period. The study was registered in the PROSPERO systematic analysis database (Protocol No. CRD42017078236) and was prepared according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The following databases were used: PubMed, BVS Regional Portal, Embase, CINAHL and Web of Science. We utilized the Newcastle-Ottawa Scale to assess the methodological quality of published studies and the Kappa coefficient to assess the agreement level between two reviewers. Of the total 1156 studies retrieved by the search strategy, 28 were considered potentially eligible (Kappa test = 0.928). Of the 28 studies, three fully met the inclusion criteria. These indicated that pulmonary lesions, such as bronchiectasis and bronchitis/bronchiolitis, were observed in patients with HTLV-1, with high-resolution computed tomography of the chest being the main method of diagnostic investigation. The analyzed cohort and case-control studies indicated an etiological relationship between HTLV-1 infection and the presence of lung lesions, with emphasis on bronchiectasis in the presence of high viral loads, as well as a higher mortality in these individuals compared with the general population.
本研究分析了人类 T 细胞嗜淋巴细胞病毒 1 型（HTLV-1）感染与肺部系统变化之间的关系。分析了 HTLV-1 与肺部系统变化之间因果关系的队列研究和病例对照研究模型。不限制语言和出版期限。该研究已在 PROSPERO 系统分析数据库中注册（方案编号 CRD42017078236），并按照系统评价和荟萃分析的推荐报告项目进行了准备。使用了以下数据库：PubMed、BVS 区域门户、Embase、CINAHL 和 Web of Science。我们使用纽卡斯尔-渥太华量表来评估已发表研究的方法学质量，并使用 Kappa 系数来评估两位评审员之间的一致性水平。通过搜索策略共检索到 1156 项研究，其中 28 项被认为具有潜在的入选资格（Kappa 检验=0.928）。在这 28 项研究中，有 3 项完全符合纳入标准。这些研究表明，HTLV-1 患者存在肺部病变，如支气管扩张和支气管炎/细支气管炎，胸部高分辨率计算机断层扫描是主要的诊断研究方法。分析的队列研究和病例对照研究表明，HTLV-1 感染与肺部病变之间存在病因关系，强调在高病毒载量时存在支气管扩张，并且这些个体的死亡率高于一般人群。
