Cachay Rodrigo, Gil-Zacarias Marcela, Watanabe-Tejada Takashi, Schwalb Alvaro, Mejía Fernando, Gayoso Oscar, Gotuzzo Eduardo
Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima 15102, Peru.
Alberto Hurtado School of Medicine, Universidad Peruana Cayetano Heredia, Lima 15102, Peru.
Pathogens. 2021 Jul 14;10(7):895. doi: 10.3390/pathogens10070895.
The lifelong infection with the human T lymphotropic virus type 1 (HTLV-1) has been associated with a variety of clinical manifestations; one of the less-explored is HTLV-1-associated pulmonary disease. Imaging of lung damage caused by the HTLV-1 hyperinflammatory cascade can be similar to sequelae from TB infection. Our study aims to describe the pulmonary lesions of HTLV-1-positive patients without past or current active TB and evaluate pulmonary function. We found that nine out of fourteen patients with no known TB disease history presented bronchiectasis, mainly found bilaterally while five presented pulmonary fibrosis. A normal pattern was found in most patients with a pulmonary functional test. Furthermore, there was no association between the PVL and the chest-CT scan findings, nor with spirometry results. However, the sample size was insufficient to conclude it.
人类嗜T淋巴细胞病毒1型（HTLV-1）的终身感染与多种临床表现相关；其中较少被探索的一种是HTLV-1相关肺部疾病。HTLV-1高炎症级联反应导致的肺损伤成像可能与结核感染的后遗症相似。我们的研究旨在描述无既往或当前活动性结核病的HTLV-1阳性患者的肺部病变，并评估肺功能。我们发现，14例无已知结核病病史的患者中有9例出现支气管扩张，主要为双侧性，5例出现肺纤维化。大多数患者的肺功能测试结果正常。此外，外周血病毒载量（PVL）与胸部CT扫描结果之间以及与肺量计结果之间均无关联。然而，样本量不足以得出结论。
