Cardiovascular Department, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Third Department of Neurology, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China.
Cardiovasc Pathol. 2020 Nov-Dec;49:107241. doi: 10.1016/j.carpath.2020.107241. Epub 2020 May 16.
In order to accelerate development of atherosclerosis(AS) in miniature swine models, varieties of strategies and methods have been explored. In addition to traditional methods such as high cholesterol feeding and balloon injury, new methods such as familial hypercholesterolemia induced by gene editing and intramural injection have been applied in recent years. Although it has been claimed that these methods have successfully aggravated lesion areas and stenosis, lesion features induced by different strategies have shown heterogeneity in morphology. In addition, time consumption, high cost, and unavailability are problems that restrict application of these AS models. Here, we summarize strategies and methods to accelerate AS models and further analyze their values, advantages, and shortcomings.
为了加速小型猪动脉粥样硬化（AS）模型的发展，已经探索了各种策略和方法。除了高胆固醇喂养和球囊损伤等传统方法外，近年来还应用了基因编辑和腔内注射引起家族性高胆固醇血症等新方法。尽管据称这些方法成功加重了病变面积和狭窄程度，但不同策略诱导的病变特征在形态上表现出异质性。此外，时间消耗、高成本和不可用性是限制这些 AS 模型应用的问题。在这里，我们总结了加速 AS 模型的策略和方法，并进一步分析了它们的价值、优点和缺点。
