Department of Research, Center Studies of Osteopathy, Catania, Italy.
Department of Biomedical and Biotechnological Sciences, University of Catania and Research Center on Motor Activities (CRAM), University of Catania Torre Biologica, Via Santa Sofia, 89, 95123, Catania, Italy.
J Complement Integr Med. 2020 Jun 18;18(1):1-7. doi: 10.1515/jcim-2020-0013.
Since 70's, scientific research has analyzed how many acute and chronic issues can affect body systems. In case of depression, chronic pain and overtraining, centrals and peripherals systems act to manage and maintain body adaptations. The aim of this study is to evaluate if the osteopathic treatment can increase the release of Cannabinoid receptor (CB) and promote the linkage with their receptors.
Documents research is based on PubMed and Google Scholar databases. Keywords used were "osteopathic treatment", "manual therapy", "endocannabinoid", "beta endorphin (BE)", and " CB1" "massage". From 70 articles collected (published in the last 10 years) 52 were excluded as non-relevant to the study aim.
The Key points have been the similar results found by different authors during different treatment periods and with different doses. From 22 articles examined, 13 have established positive effects on CB increasing post osteopathic treatment, three articles have indicated the most targeted tissues in which the substances are most expressed, two articles indicate how physical activities produce antalgic effects by increasing CB's values.
As a result of this review, osteopathic manipulation treatment seems to be a valid and effective instrument for the treatment of a series of pathologies such as chronic low back pain, fibromyalgia, spinal cord lesions, myofascial graft point, migraine, GI tract dysfunctions, and depression.
自 70 年代以来，科学研究已经分析了许多急性和慢性问题如何影响身体系统。在抑郁症、慢性疼痛和过度训练的情况下，中枢和外周系统会作用于管理和维持身体适应。本研究旨在评估整骨治疗是否能增加大麻素受体 (CB) 的释放，并促进其与受体的结合。
文献研究基于 PubMed 和 Google Scholar 数据库。使用的关键词是“整骨治疗”、“手法治疗”、“内源性大麻素”、“β-内啡肽 (BE)”和“CB1”“按摩”。从收集的 70 篇文章（发表在过去 10 年内）中，有 52 篇被排除在研究目的之外，因为与研究目的无关。
不同作者在不同治疗期间和不同剂量下发现了相似的结果，这是关键点。在检查的 22 篇文章中，有 13 篇文章证实了整骨治疗后 CB 增加的积极影响，有 3 篇文章指出了物质表达最多的靶向组织，有 2 篇文章表明体育活动如何通过增加 CB 值产生镇痛作用。
由于这项综述，整骨手法治疗似乎是治疗一系列疾病的有效工具，如慢性下腰痛、纤维肌痛、脊髓损伤、肌肉筋膜移植物点、偏头痛、胃肠道功能障碍和抑郁症。
